Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

358 questions · 360 findings · 31 reviews · Vascular

No studies found 86 · 23.9%GRADE not reported 15 · 4.2%Very low 40 · 11.1%Low 117 · 32.5%Moderate 90 · 25%High 12 · 3.3%

Sclerotherapy vs placebo

Adverse events ‐ hyperpigmentation ( · people with telangiectasias and reticular veins

Sclerotherapy probably leads to higher adverse events ‐ hyperpigmentation ( compared with placebo (moderate certainty).

1 finding from 1 review

Sclerotherapy vs placebo

Adverse events ‐ matting ( · people with telangiectasias and reticular veins

Sclerotherapy probably leads to higher adverse events ‐ matting ( compared with placebo (moderate certainty).

1 finding from 1 review

EDTA vs placebo

Coronary heart disease mortality – CHD deaths · atherosclerotic cardiovascular disease

It is very uncertain whether EDTA changes coronary heart disease death compared with placebo (very low certainty).

1 finding from 1 review