Findings

What do systematic reviews say?

201 questions · 209 findings · 10 reviews · Common Mental Disorders

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No studies found 69 · 33%GRADE not reported 1 · 0.5%Very low 69 · 33%Low 40 · 19.1%Moderate 23 · 11%High 7 · 3.3%

Antidepressants vs antipsychotics

Quality of life · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs antipsychotics

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.86 [1.23, 2.82]
2 studies · 148 participants
Very low

Antidepressant plus antipsychotic vs placebo

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.75 [0.48, 1.18]
2 studies · 148 participants
Very low

Antidepressant plus antipsychotic vs placebo

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo

Quality of life · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Clinical response of depression · adults with psychotic depression

Antidepressant plus antipsychotic may leads to higher clinical response of depression compared with placebo plus antipsychotic (low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.83 [1.4, 2.38]
4 studies · 447 participants
Low

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antipsychotic (very low certainty).

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.79 [0.63, 1.01]
4 studies · 447 participants
Very low

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Quality of life · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo/no adjunctive treatment + antipsychotics

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.42 [1.11, 1.8]
4 studies · 245 participants
Very low
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.7 [1.19, 2.43]
3 studies · 157 participants
Very low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 0.91 [0.55, 1.5]
4 studies · 245 participants
Very low
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
RR 1.04 [0.52, 2.07]
3 studies · 157 participants
Very low

Antidepressant plus antipsychotic vs placebo plus antidepressant

Depression remission · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressants vs placebo

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Antidepressant plus antipsychotic vs placebo plus antidepressant

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Pharmacological treatment for psychotic depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found