Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

324 questions · 328 findings · 34 reviews · Headline outcomes only

No studies found 82 · 25%GRADE not reported 8 · 2.4%Very low 75 · 22.9%Low 105 · 32%Moderate 45 · 13.7%High 13 · 4%

NSAIDs vs placebo or no treatment

AKI within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes AKI within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

RRT within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes RRT within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

Death (all causes) · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes death (all causes) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

Length of hospital stay · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes length of hospital stay compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Summary of findings for NSAIDs plus corticosteroids vs corticosteroids

Proportion of participants with cystoid macular edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs plus corticosteroids may leads to lower proportion of participants with cystoid macular edema 1 week compared with corticosteroids alone (low certainty).

1 finding from 1 review

Summary of findings for NSAIDs plus corticosteroids vs corticosteroids

Intraocular inflammation measured by proportion of participants with corneal edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs plus corticosteroids showed no clear difference in intraocular inflammation measured by proportion of participants with… compared with corticosteroids alone (moderate certainty).

1 finding from 1 review