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What do systematic reviews say?

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Evidence found and GRADE certainty

958 questions · 991 findings · 123 reviews · Headline outcomes only

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No studies found 177 · 17.9%GRADE not reported 25 · 2.5%Very low 230 · 23.2%Low 321 · 32.4%Moderate 185 · 18.7%High 53 · 5.3%

Intravenous midazolam vs placebo

Allergic or anaphylactoid reaction · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs diazepam

Anxiety · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in numeric rating of anxiety or rated as anxious compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Anterograde amnesia (defined by number of participants who recalled the procedure) · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam may leads to lower anterograde amnesia (defined by number of participants who recalled… compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Disinhibition or excitation · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs diazepam

Discomfort/pain · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in discomfort/pain compared with diazepam (low certainty).

1 finding from 1 review

Intravenous midazolam vs diazepam

Allergic or anaphylactoid reaction · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Mortality before hospital discharge · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

IVIg vs placebo or no intervention

All‐cause mortality, neonates, standard polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

IVIg vs placebo or no intervention

All‐cause mortality, neonates, IgM‐enriched polyclonal IVIG · neonates with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) showed no clear difference in all‐cause mortality, neonates, IgM‐enriched polyclonal IVIG compared with placebo or no intervention (low certainty).

1 finding from 1 review

IVIg vs placebo or no intervention

28‐Day all cause mortality (adult studies) · adult patients with sepsis, severe sepsis and septic shock

Polyclonal intravenous immunoglobulin (IVIG) probably leads to lower all‐cause mortality, adults, standard polyclonal IVIG compared with placebo or no intervention (moderate certainty).

5 findings from 1 review
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