Findings

What do systematic reviews say?

172 questions · 181 findings · 11 reviews

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No studies found 35 · 19.3%GRADE not reported 3 · 1.7%Very low 68 · 37.6%Low 70 · 38.7%Moderate 5 · 2.8%High 0 · 0%

Progesterone vs placebo/no treatment

Adverse events, OHSS, preterm delivery, congenital anomaly · women with oral (clomiphene citrate or letrozole) stimulation

The review found no eligible studies for this question.

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Progesterone vs placebo/no treatment

Live birth or ongoing pregnancy · women with gonadotropin stimulation

Progesterone showed no clear difference in live birth rate/ongoing pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.24 [0.8, 1.92]
4 studies · 1054 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with gonadotropin stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.68 [0.24, 1.91]
2 studies · 102 participants
Low

Metformin vs placebo co‐treatment

Live birth rate per woman · subfertile women with polycystic ovary syndrome

Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.31 [1.24, 4.33]
2 studies · 180 participants
Low

Metformin vs placebo co‐treatment

Multiple pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin showed no clear difference in multiple pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 0.55 [0.15, 1.95]
4 studies · 232 participants
Low

Metformin vs placebo co‐treatment

Ongoing pregnancy · subfertile women with polycystic ovary syndrome

Metformin may leads to higher ongoing pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.46 [1.36, 4.46]
4 studies · 232 participants
Low

Metformin vs placebo co‐treatment

Clinical pregnancy rate · subfertile women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.51 [1.46, 4.31]
5 studies · 264 participants
Low

IUI vs FSP

Live birth rate per couple · women with non‐tubal infertility

IUI showed no clear difference in live birth per couple compared with FSP (low certainty).

1 finding from 1 review

Intrauterine insemination versus fallopian tube sperm perfusion for non‐tubal infertility 2013 · Cochrane Headline outcomes only
OR 0.94 [0.59, 1.49]
3 studies · 633 participants
Low

IUI vs FSP

Clinical pregnancy rate · women with non‐tubal infertility

IUI showed no clear difference in clinical pregnancy per couple compared with FSP (low certainty).

1 finding from 1 review

Intrauterine insemination versus fallopian tube sperm perfusion for non‐tubal infertility 2013 · Cochrane Headline outcomes only
OR 0.75 [0.49, 1.12]
14 studies · 1745 participants
Low

IUI vs FSP

Multiple pregnancy · women with non‐tubal infertility

IUI showed no clear difference in multiple pregnancy per couple compared with FSP (low certainty).

1 finding from 1 review

Intrauterine insemination versus fallopian tube sperm perfusion for non‐tubal infertility 2013 · Cochrane Headline outcomes only
OR 0.62 [0.29, 1.32]
7 studies · 908 participants
Low

IUI vs FSP

Miscarriage per couple · women with non‐tubal infertility

IUI showed no clear difference in miscarriage per couple compared with FSP (low certainty).

1 finding from 1 review

Intrauterine insemination versus fallopian tube sperm perfusion for non‐tubal infertility 2013 · Cochrane Headline outcomes only
OR 1.07 [0.56, 2.05]
7 studies · 884 participants
Low

IUI vs FSP

Ectopic pregnancy rate per couple · women with non‐tubal infertility

It is very uncertain whether IUI changes ectopic pregnancy per couple compared with FSP (very low certainty).

1 finding from 1 review

Intrauterine insemination versus fallopian tube sperm perfusion for non‐tubal infertility 2013 · Cochrane Headline outcomes only
OR 0.88 [0.24, 3.19]
4 studies · 643 participants
Very low