Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

502 questions · 519 findings · 57 reviews · Hepato-Biliary

No studies found 131 · 25.2%GRADE not reported 11 · 2.1%Very low 302 · 58.2%Low 46 · 8.9%Moderate 27 · 5.2%High 2 · 0.4%

Radix Sophorae flavescentis vs placebo or no intervention

Proportion of participants with detectable HBV‐DNA in serum or plasma (at maximum · chronic hepatitis B

It is very uncertain whether radix Sophorae flavescentis changes surrogate outcomes: Proportion of participants with detectable… compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Cysteamine vs no intervention

Hepatotoxicity (aspartate aminotransferase > 1000 IU/L) · people with paracetamol (acetaminophen) overdose

Cysteamine may leads to lower hepatotoxicity (aspartate aminotransferase > 1000 IU/L) compared with no intervention (low certainty).

1 finding from 1 review

Thiazolidinediones vs no intervention

Serious adverse events (number of events) · people with non‐alcohol‐related fatty liver disease (NAFLD)

It is very uncertain whether thiazolidinediones changes serious adverse events (number of events) compared with no intervention (very low certainty).

1 finding from 1 review