Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

259 questions · 268 findings · 33 reviews

No studies found 56 · 20.9%GRADE not reported 21 · 7.8%Very low 68 · 25.4%Low 64 · 23.9%Moderate 49 · 18.3%High 10 · 3.7%

Responsive complementary feeding (RCF) / other caregivers' feeding practices vs Other models of complementary feeding (traditional/non-responsive CF)

Type 2 diabetes (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No eligible studies examined the influence of complementary feeding practices on later type 2 diabetes; this is an evidence gap.

1 finding from 1 review

Responsive complementary feeding (RCF) vs Other models of complementary feeding (traditional/non-responsive CF)

Physical growth / weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

Two RCTs suggest responsive complementary feeding leads to better weight gain in the first two years, though effects were small and not always sustained (ungraded).

1 finding from 1 review

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction
1 finding from 1 review

Responsive complementary feeding (RCF) / other caregivers' feeding practices vs Other models of complementary feeding (traditional/non-responsive CF)

Hypertension (later in life) · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No eligible studies examined the influence of complementary feeding practices on later hypertension; this is an evidence gap.

1 finding from 1 review

Baby-Led Introduction to SolidS (BLISS) vs Traditional complementary feeding (TCF)

Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

In RCTs, BLISS did not significantly change overweight/obesity risk versus traditional feeding (RR 0.15, 95% CI 0.00 to 17.79; low certainty).

1 finding from 1 review

Responsive / non-responsive complementary feeding (RCF/NRCF) vs Other models of complementary feeding

Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No systematic reviews or studies assessed choking risk for RCF or NRCF (only BLW/BLISS); this is an evidence gap.

1 finding from 1 review

Baby-led weaning (BLW) / BLISS vs Traditional complementary feeding (TCF)

Choking · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No significant difference in choking risk was found between BLW/BLISS-fed and traditionally fed infants (ungraded).

1 finding from 1 review

Responsive complementary feeding (RCF) / other caregivers' feeding practices vs Other models of complementary feeding (traditional/non-responsive CF)

Dental caries · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No eligible studies examined the influence of complementary feeding practices on later dental caries; this is an evidence gap.

1 finding from 1 review

High vs standard volume of unfortified human milk or term formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

1 finding from 1 review

High vs standard volume of fortified human milk or preterm formula

Extrauterine growth restriction at discharge · preterm or low birth weight infants

High showed no clear difference in extrauterine growth restriction at discharge compared with standard volume of fortified human milk or preterm formula (low certainty).

1 finding from 1 review

High vs standard volume of fortified human milk or preterm formula

Necrotising enterocolitis · preterm or low birth weight infants

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of fortified human milk or preterm formula (very low certainty).

1 finding from 1 review

Prophylaxis with standard therapeutic factor concentrate vs pegylated liposome FVIII formulation

Annualized joint Bleeding Rate (AjBR) · children or adults with hemophilia A

Prophylaxis with standard therapeutic factor concentrate showed no clear difference in AJBR compared with pegylated liposome FVIII formulation (low certainty).

1 finding from 1 review