Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

351 questions · 368 findings · 41 reviews · Headline outcomes only

No studies found 47 · 12.8%GRADE not reported 16 · 4.3%Very low 68 · 18.5%Low 92 · 25%Moderate 97 · 26.4%High 48 · 13%

160/4.5 mcg BDF single inhaler therapy vs current best practice

Hospital admissions due to exacerbations: number of participants · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in patients with exacerbations causing hospitalisation compared with current best practice (low certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Rate of exacerbations requiring systemic corticosteroids · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy probably leads to lower patients with exacerbations treated with oral steroids compared with current best practice (moderate certainty).

1 finding from 1 review