Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

228 questions · 231 findings · 20 reviews · Headline outcomes only

No studies found 32 · 13.9%GRADE not reported 4 · 1.7%Very low 46 · 19.9%Low 80 · 34.6%Moderate 53 · 22.9%High 16 · 6.9%

Moxibustion + conventional treatment vs Western medicine

Patient‐reported symptom: nausea/vomiting (WHO grade 3 to 4) · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion + conventional treatment may leads to lower patient‐reported symptom: nausea/vomiting (WHO grade 3 to 4) compared with conventional medicine alone (low certainty).

1 finding from 1 review

Moxibustion + conventional treatment vs Western medicine

Diarrhoea · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion + conventional treatment showed no clear difference in patient‐reported symptom: diarrhoea compared with conventional medicine alone (low certainty).

1 finding from 1 review

Moxibustion + conventional treatment vs Western medicine

Haemoglobin (g/dL) · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion + conventional treatment may leads to higher objective outcome measure: haemoglobin (g/L) compared with conventional medicine alone (low certainty).

1 finding from 1 review

Moxibustion + conventional treatment vs Western medicine

Objective outcome measure: platelets (× 109/L) · Patients with cancer receiving chemotherapy and/or radiotherapy

Moxibustion + conventional treatment showed no clear difference in objective outcome measure: platelet (× 109/L) compared with conventional medicine alone (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Duration of grade IV neutropenia (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in duration of grade IV neutropenia (lower values signify better… compared with antibiotics alone (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to recovery from fever (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to recovery from fever (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Time to withdrawal from ATB (lower values signify better outcomes) · people with chemotherapy‐induced febrile neutropenia

Benefits and harms of CSF plus antibiotics showed no clear difference in time to withdrawal from ATB (lower values signify better outcomes) compared with antibiotics alone (low certainty).

1 finding from 1 review

EGFR tyrosine kinase inhibitor (TKI) vs observation

Progression‐free survival · maintenance treatment of epithelial ovarian cancer after first‐line chemotherapy

It is very uncertain whether EGFR tyrosine kinase inhibitor (TKI) changes progression‐free survival compared with observation alone (very low certainty).

1 finding from 1 review

Hysterectomy (simple or radical) with radiotherapy vs Radiotherapy alone

Progression‐free survival (PSF) · women with locally advanced cervical cancer

Hysterectomy (simple or radical) with radiotherapy showed no clear difference in progression‐free survival Median compared with radiotherapy alone (low certainty).

1 finding from 1 review