Summary of findings for imiquimod probably leads to higher fatigue ‐ any grade compared with cidofovir (moderate certainty).
Summary of findings for imiquimod probably leads to higher headache ‐ any grade compared with cidofovir (moderate certainty).
Summary of findings for imiquimod showed no clear difference in total serious adverse events compared with cidofovir (moderate certainty).
Summary of findings for imiquimod showed no clear difference in treatment discontinuation compared with cidofovir (moderate certainty).
The intervention showed no clear difference in laser vaporisation versus CUSA (low certainty).
Summary of findings for imiquimod leads to higher response to treatment at 5 to 6 months ‐ complete response compared with placebo (high certainty).
Summary of findings for imiquimod probably leads to higher response to treatment at 12 months ‐ overall response compared with placebo (moderate certainty).
Summary of findings for imiquimod showed no clear difference in progression to vulval cancer at 12 months compared with placebo (low certainty).
Summary of findings for imiquimod leads to lower HPV DNA persistence compared with placebo (high certainty).
Summary of findings for imiquimod leads to higher pain ‐ any grade compared with placebo (high certainty).
Summary of findings for imiquimod leads to higher dose reductions compared with placebo (high certainty).
Summary of findings for imiquimod showed no clear difference in response to treatment at 6 months ‐ overall response compared with cidofovir (moderate certainty).
It is very uncertain whether SUMMARY OF FINDINGS FOR DECOMPRESSION changes pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with FUSION (very low certainty).
SUMMARY OF FINDINGS FOR DECOMPRESSION leads to lower reoperations Number of patients requiring a revision surgery compared with INTERSPINOUS SPACERS (high certainty).
SUMMARY OF FINDINGS FOR FUSION showed no clear difference in pain Long‐term (≥ 12 months) Pain scores converted to 0 to 100 scale… compared with INTERSPINOUS SPACERS (low certainty).
SUMMARY OF FINDINGS FOR FUSION may leads to higher disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with INTERSPINOUS SPACERS (low certainty).
It is very uncertain whether SUMMARY OF FINDINGS FOR FUSION changes operation time Duration of operation reported in minutes compared with INTERSPINOUS SPACERS (very low certainty).
SUMMARY OF FINDINGS FOR FUSION probably leads to higher blood loss Amount of perioperative blood loss reported in mL compared with INTERSPINOUS SPACERS (moderate certainty).
SUMMARY OF FINDINGS FOR FUSION showed no clear difference in reoperations Number of patients requiring a revision surgery compared with INTERSPINOUS SPACERS (high certainty).
It is very uncertain whether SUMMARY OF FINDINGS FOR DECOMPRESSION changes disability Long‐term (≥ 12 months) Disability scores converted to 0… compared with FUSION (very low certainty).