Patients with one or more adverse events · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.
1 finding from 1 review
Participant‐reported pain relief of 50% or greater · Patients requiring surgical removal of a lower wisdom tooth or teeth, with baseline moderate to severe pain (surgery under local…
Paracetamol (single oral dose, any dose or formulation; subgroups up… led to higher achieving at least 50% pain relief at 6 hours (using pain relief… compared with placebo; GRADE not reported.
1 finding from 1 review
Pulp exposure rate · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal was associated with a lower mean pulp exposure rate than conventional removal (1.2% vs 8.1%), but the difference was not statistically significant (Wilcoxon, p = 0.068); certainty of evidence was not graded.
1 finding from 1 review
Mean pulp-exposure percentage (unweighted study-level mean, 4 studies) MIT 1.2% vs CT 8.1% (Wilcoxon = 0.0, p = 0.068; not statistically significant)
4 studies · 791 participants
GRADE not reported
White spot lesion area · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no significant difference in WSL area, with certainty not graded.
1 finding from 1 review
There was no significant difference in the WSL area between the two groups, with the mean WSL area measuring 161.3 mm2 in the Opal Seal group and 1361.2 mm2 in the conventional group.
1 study · 56 participants
GRADE not reported
Streptococcus mutans count · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
TiO2-modified composite showed no S. mutans difference, with certainty not graded.
1 finding from 1 review
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no difference in WSL incidence, with certainty not graded.
1 finding from 1 review
The incidence of WSLs in the Clearfil (CF) group was 8.03%, while in the Transbond (TB) group, it was 9.24% with no significant difference (p = 0.82).
1 study · 35 participants
GRADE not reported
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal had fewer DIAGNOdent-measured lesions, with certainty not graded.
1 finding from 1 review
Opal Seal group showed fewer WSLs compared to the Transbond group, with initial demineralization rates of 1.3% and 3.9%, and caries lesion rates of 0.2% and 1.3%, respectively (p <0.03).
1 study · 56 participants
GRADE not reported
Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no difference in photographic WSL severity, with certainty not graded.
1 finding from 1 review
Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer favored lower demineralization scores, but certainty was not graded.
1 finding from 1 review
Statistically significant scores in favor of the nCaF2 primer at T1, T3, and T6 (p-value = 0.000).
1 study · 31 participants
GRADE not reported
Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Opal Seal showed no difference in bracket failure, with certainty not graded.
1 finding from 1 review
No significant differences were observed in bracket failure rates among different primers, dental arches, bracket types, or sexes.
1 study · 56 participants
GRADE not reported
White spot lesion incidence · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The self-etch primer system had higher WSL incidence than the conventional system, with certainty not graded.
1 finding from 1 review
White spot lesions assessed by laser fluorescence (DIAGNOdent) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single small split-mouth RCT found the nCaF2-containing primer reduced demineralization (DIAGNOdent) but showed no significant clinical white spot lesion difference at debonding (ungraded).
1 finding from 1 review
Photographic white spot lesion score · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
nCaF2 primer showed no clinical photographic WSL difference at debonding, with certainty not graded.
1 finding from 1 review
Intervention not reported
Pathogenic bacteria / plaque composition around brackets (fewer pathogenic bacteria with flash-free vs APC; comparable plaque quantity)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Pain with dilationa,b · people requesting a surgical abortion at less than 11 weeks' gestation
1 finding from 1 review
Pain during procedure in women who also received topical cervical lidocaine spraya,b · people requesting a surgical abortion at seven weeks' gestation or less
1 finding from 1 review
Pain with dilation ‐ not measured · women requesting a surgical abortion at seven to 12 weeks of gestation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pain with aspirationa,b · women requesting a surgical abortion at seven to 12 weeks of gestation
1 finding from 1 review
Pain during procedure ‐ not measured · women requesting a surgical abortion at seven to 12 weeks of gestation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Pain with dilation ‐ not measured · people requesting a surgical abortion at 5+0 to 7+0 weeks' gestation
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found