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What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

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No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Doxycycline vs tetracycline

Resolution of fever within 48 hours · adults with scrub typhus

Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Intervention not reported

Case fatality at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in case fatality at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Poor functional outcome at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in poor functional outcome at the end of (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of infections at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention leads to lower number of infections at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Number of UTIs at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention leads to lower number of UTIs at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Number of pneumonias at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in number of pneumonias at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Death · children and adults with acute bacterial meningitis

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological disability · children and adults with acute bacterial meningitis

The intervention showed no clear difference in neurological disability (low certainty).

1 finding from 1 review