Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Intervention not reported

Bradycardia (within 30 days; as defined by study authors, minimum heart rate < 60 beats per minute or requiring medication) · adults undergoing cardiac surgery under general anaesthesia

The intervention showed no clear difference in bradycardia (within 30 days; as defined by study authors, minimum… (low certainty).

1 finding from 1 review

Intervention not reported

Hypotension (within 30 days; as defined by study authors, minimum systolic blood pressure < 90 mmHg or requiring medication) · adults undergoing cardiac surgery under general anaesthesia

The intervention showed no clear difference in hypotension (within 30 days; as defined by study authors, minimum… (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Early all‐cause mortality (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers showed no clear difference in early all‐cause mortality (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Myocardial infarction (0 to 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to lower acute myocardial infarction (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Cerebrovascular events (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers showed no clear difference in cerebrovascular events (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Ventricular arrhythmias (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

It is very uncertain whether perioperative beta‐blockers changes ventricular arrhythmias (within 30 days) compared with placebo or standard care (very low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Atrial fibrillation or atrial flutter, or both (within 30 days) · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to lower atrial fibrillation or atrial flutter, or both (within 30 days) compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Bradycardia · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers may leads to higher bradycardia (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (low certainty).

1 finding from 1 review

Perioperative beta‐blockers vs placebo or usual care

Hypotension · adults undergoing non‐cardiac surgery under general anaesthesia (to include: low‐risk, medium‐risk, and high‐risk surgeries)

Perioperative beta‐blockers probably leads to higher hypotension (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (moderate certainty).

1 finding from 1 review

Autologous vein vs other graft types

Primary patency ( · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

Autologous vein may leads to lower primary patency (24 months) compared with other graft types (low certainty).

2 findings from 1 review

Externally supported graft vs unsupported graft

Primary patency ( · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

The review found no eligible studies for this question.

2 findings from 1 review

PTFE vs PTFE with vein cuff

Primary patency ( · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

It is very uncertain whether PTFE changes primary patency (24 months) compared with PTFE with vein cuff (very low certainty).

2 findings from 1 review

PTFE vs PTFE with vein cuff

Secondary patency (24 months) · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

It is very uncertain whether PTFE changes secondary patency (24 months) compared with PTFE with vein cuff (very low certainty).

1 finding from 1 review

PTFE vs PTFE with vein cuff

Limb salvage · people with peripheral vascular disease requiring below‐knee femoro‐popliteal bypass surgery

PTFE showed no clear difference in limb salvage (24 months) compared with PTFE with vein cuff (low certainty).

1 finding from 1 review

Autologous vein vs other graft types

Secondary patency (24 months) · people with peripheral vascular disease requiring above‐knee femoro‐popliteal bypass surgery

Autologous vein may leads to lower secondary patency (60 months) compared with other graft types (low certainty).

1 finding from 1 review