What do systematic reviews say?

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

FIBRINOGEN: Therapeutic trials: intervention showed no clear difference in all‐cause mortality In‐hospital mortality up to 30 days… compared with inactive Control (low certainty).

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  RR 5 [0.25, 102]
  1 study · 120 participants
  Low

FXIII: Prophylactic trials: intervention vs inactive control

FXIII: Prophylactic trials: intervention showed no clear difference in venous thromboembolic events ‐ Up to 5 to 7 weeks post‐operatively compared with inactive control (low certainty).

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  RR 0.93 [0.06, 14.67]
  2 studies · 282 participants
  Low
• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Very low

FXIII: Prophylactic trials: intervention vs inactive control

FXIII: Prophylactic trials: intervention showed no clear difference in venous thromboembolic events Up to 30 days post‐operatively compared with inactive control (low certainty).

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  RR 3 [0.14, 66.53]
  1 study · 22 participants
  Low

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 294 participants
  Low

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

FIBRINOGEN: Therapeutic trials: intervention showed no clear difference in all‐cause mortality Up to 46 days post‐operatively compared with inactive Control (high certainty).

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  RR 0.23 [0.05, 1.01]
  2 studies · 213 participants
  High

FIBRINOGEN: Therapeutic trials: intervention vs haemostatically active control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 63 participants
  Moderate

FIBRINOGEN: Therapeutic trials: intervention vs haemostatically active control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Low
• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  RR 0.95 [0.06, 14.3]
  1 study · 43 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs inactive control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  Low

FIBRINOGEN: Prophylactic trials: intervention vs inactive control

• Pro‐coagulant haemostatic factors for the prevention and treatment of bleeding in people without haemophilia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Moderate

Summary of findings table: Art therapy vs active control

• Art therapy for people with dementia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Very low

Summary of findings table: Art therapy vs active control

• Art therapy for people with dementia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Very low

Summary of findings table: Art therapy vs active control

• Art therapy for people with dementia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 21 participants
  Very low

Summary of findings table: Art therapy vs active control

• Art therapy for people with dementia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 39 participants
  Very low

Summary of findings table: Art therapy vs active control

• Art therapy for people with dementia 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 60 participants
  Very low

Grommets vs active monitoring

Grommets may leads to higher proportion of patients who have no AOM recurrences at 6 months… compared with active monitoring (low certainty).

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  RR 9.49 [2.38, 37.8]
  1 study · 95 participants
  Low

Grommets vs active monitoring

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 54 participants
  Low

Grommets vs active monitoring

Grommets showed no clear difference in proportion of patients who have no AOM recurrences at 12 months… compared with active monitoring (low certainty).

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  RR 1.41 [1, 1.99]
  1 study · 200 participants
  Low

Grommets vs active monitoring

Grommets showed no clear difference in total number of AOM recurrences at 6 months post‐randomisation compared with active monitoring (low certainty).

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 95 participants
  Low

Grommets vs active monitoring

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 200 participants
  Low

Grommets vs active monitoring

• Grommets (ventilation tubes) for recurrent acute otitis media in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 85 participants
  Low