Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Polymyxins vs aminoglycosides

Response rate ‐ improvement in sputum purulence · adults with bronchiectasis

It is very uncertain whether polymyxins changes response rate ‐ improvement in sputum purulence compared with aminoglycosides (very low certainty).

1 finding from 1 review

Fluoroquinolones vs amoxicillin

Response rate ‐ treatment failure · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

Fluoroquinolones may leads to lower response rate ‐ treatment failure compared with amoxicillin (low certainty).

1 finding from 1 review

Fluoroquinolones vs amoxicillin

Response rate ‐ microbiological response · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

Fluoroquinolones may leads to higher response rate ‐ microbiological response compared with amoxicillin (low certainty).

1 finding from 1 review

Fluoroquinolones vs amoxicillin

Response rate ‐ improvement in sputum purulence (excellent) · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

It is very uncertain whether fluoroquinolones changes response rate ‐ improvement in sputum purulence (excellent) compared with amoxicillin (very low certainty).

1 finding from 1 review

Metronidazole vs vancomycin

Cure (combined symptomatic and bacteriologic cure) ‐ mild disease · patients with Clostridium difficile‐associated diarrhoea in adults

It is very uncertain whether metronidazole changes cure (combined symptomatic and bacteriologic cure) ‐ mild disease compared with vancomycin (very low certainty).

1 finding from 1 review

Metronidazole vs vancomycin

Cure (combined symptomatic and bacteriologic cure) ‐ severe disease · patients with Clostridium difficile‐associated diarrhoea in adults

It is very uncertain whether metronidazole changes cure (combined symptomatic and bacteriologic cure) ‐ severe disease compared with vancomycin (very low certainty).

1 finding from 1 review