Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · Oral Health

No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Transbond Plus self etching primer (3M Unitek) vs First Step self etching primer (Reliance Orthodontic Products)

Bond failure rate · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Noble 2006 (split-mouth) compared Transbond Plus versus First Step SEP; the bond failure rate was reported at tooth level rather than at participant level and was not amenable to analysis; the evidence was insufficient…
    1 study
    GRADE not reported

Different etching materials (phosphoric acid, polyacrylic acid, maleic acid, etc.), acid concentrations or etching times vs An alternative etching material, concentration or etching time

Outcome not reported · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review
  • We identified no eligible trial that examined the effects of conventional etchants with respect to different etching concentrations or etching times for the bonding of fixed orthodontic appliances. No eligible RCTs…
    Studies not reported
    No studies found

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Participant satisfaction · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars

The review found no eligible studies for this question.

1 finding from 1 review

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Aesthetics · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

PDHA program vs Baseline pre-intervention service-delivery scenario

School-based oral health promotion services · Alaska children

The PDHA program was projected to raise school-based oral health promotion service receipt from 53% to more than 90%, without a GRADE rating.

1 finding from 1 review

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

Measures of clinical activity: mean percentage of 12- to 14-year-olds receiving fissure sealants for second permanent molars per dentist (weighted by number of children seen) - adjusted · Dentists seeing children with erupted second permanent molars (Scotland, in areas representing the four most deprived categories out of…

It is very uncertain whether fee-for-service remuneration changes measures of clinical activity: mean percentage of 12- to… compared with no specific intervention (control) (very low certainty).

1 finding from 1 review

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

Assessment of the alignment of the lower front teeth using any method or index · Participants who previously underwent orthodontic treatment, with subsequent crowding (relapse) of the lower front teeth (lower incisors…

The review found no eligible studies for this question.

1 finding from 1 review

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Decay (decalcification) associated with or around the etching field · Children and adults with fixed orthodontic brackets bonded to incisors, canines and premolars
1 finding from 1 review
  • Decay (decalcification) associated with or around the etching field: Only one study (Ghiz 2009) assessed this outcome but data were reported at the tooth level rather than at the participant level and therefore was not…
    1 study · 25 participants
    GRADE not reported

Multivitamin vs placebo

Average mouth pain during RAS episodes · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Daily multivitamin showed no clear difference in average mouth pain during RAS episodes compared with placebo; GRADE not reported.

1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Decrease in frequency of attacks · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Levamisole (150 mg per day) showed no clear difference in decrease in frequency of attacks compared with placebo; GRADE not reported.

1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Rofecoxib (oral, 50 mg on first day then 25 to 50 mg per day for 4 days) vs Tinidazole (1 g per day for 3 days)

Total effective rate at 4 days · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Rofecoxib (oral, 50 mg on first day then 25 to 50 mg per day for 4… showed no clear difference in total effective rate at 4 days compared with tinidazole (1 g per day for 3 days); GRADE not reported.

1 finding from 1 review

Bee propolis (one 500 mg capsule per day) vs placebo

Quality of life · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Levamisole (150 mg per day) vs placebo

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo

Mean VAS pain per day · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) showed no clear difference in mean VAS pain per day compared with placebo; GRADE not reported.

1 finding from 1 review