What do systematic reviews say?

Summary of findings table ‐ LSSS intervention vs regular salt

Summary of findings table ‐ LSSS intervention showed no clear difference in hypertension compared with regular salt (low certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  RR 0.97 [0.9, 1.03]
  1 study · 2566 participants
  Low

Summary of findings table ‐ LSSS intervention vs regular salt

It is very uncertain whether summary of findings table ‐ LSSS intervention changes blood pressure control compared with regular salt (very low certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  RR 2.12 [1.32, 3.41]
  2 studies · 253 participants
  Very low

Summary of findings table ‐ LSSS intervention vs regular salt

It is very uncertain whether summary of findings table ‐ LSSS intervention changes cardiovascular events: various compared with regular salt (very low certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  RR 1.22 [0.49, 3.04]
  5 studies · 982 participants
  Very low

Summary of findings table ‐ LSSS intervention vs regular salt

Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular events: non‐fatal stroke compared with regular salt (moderate certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  RR 0.9 [0.8, 1.01]
  3 studies · 21250 participants
  Moderate

Summary of findings table ‐ LSSS intervention vs regular salt

Summary of findings table ‐ LSSS intervention probably leads to lower cardiovascular events: non‐fatal acute coronary syndrome (events per… compared with regular salt (moderate certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  Rate ratio 0.7 [0.52, 0.94]
  1 study · 20995 participants
  Moderate

Summary of findings table ‐ LSSS intervention vs regular salt

Summary of findings table ‐ LSSS intervention showed no clear difference in cardiovascular mortality (events per 100,000 person‐years) compared with regular salt (moderate certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  Rate ratio 0.77 [0.6, 1]
  3 studies · 23200 participants
  Moderate

Summary of findings table ‐ LSSS intervention vs regular salt

It is very uncertain whether summary of findings table ‐ LSSS intervention changes stroke mortality (events per 100,000 person‐years) compared with regular salt (very low certainty).

• Replacing salt with low‐sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women 2022 · Cochrane Headline outcomes only
  Rate ratio 0.64 [0.33, 1.25]
  2 studies · 21423 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 164 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Continuous infusion vs forced (or pulse) infusion of thrombolytic agents

• Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 304 participants
  Very low

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher local recurrence‐free survival ‐ total (LR‐FS) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 1.21 [1.03, 1.42]
  8 studies · 13168 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher cosmesis, physician/nurse‐reported compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  OR 1.57 [1.31, 1.87]
  6 studies · 3652 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI showed no clear difference in overall survival compared with WBRT (high certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 0.99 [0.88, 1.12]
  8 studies · 13175 participants
  High

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI probably leads to higher subcutaneous fibrosis (late RT toxicity) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  OR 5.07 [3.81, 6.74]
  2 studies · 3011 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI showed no clear difference in cause‐specific survival (C‐SS) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 1.06 [0.83, 1.36]
  7 studies · 9865 participants
  Moderate

Summary of Findings Table ‐ PBI?APBI vs WBRT

Summary of Findings Table ‐ PBI?APBI showed no clear difference in distant metastasis‐free survival (DM‐FS) compared with WBRT (moderate certainty).

• Partial breast irradiation versus whole breast radiotherapy for early breast cancer 2021 · Cochrane Headline outcomes only
  HR 0.95 [0.8, 1.13]
  7 studies · 11033 participants
  Moderate