Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,841 questions · 1,893 findings · 109 reviews · Headline outcomes only

No studies found 546 · 28.8%GRADE not reported 117 · 6.2%Very low 613 · 32.4%Low 473 · 25%Moderate 118 · 6.2%High 26 · 1.4%

Intervention not reported

Clinical improvement in pulse rate · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Improvement in heart rate · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Duration of hospitalisation · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Clinically important adverse events · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient satisfaction · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in overall seizure frequency) · people with epilepsy and intellectual disability

The intervention may leads to higher responder rate (≥ 50% reduction in overall seizure frequency) (low certainty).

1 finding from 1 review

Intervention not reported

Responder rate (≥ 50% reduction in rate of drop seizures) · people with epilepsy and intellectual disability

The intervention showed no clear difference in responder rate (≥ 50% reduction in rate of drop seizures) (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 4 studies reported the frequency of self reported adverse events in the AED and placebo groups The results show a trend in favour of the placebo groups · people with epilepsy and intellectual disability

The intervention showed no clear difference in adverse events 4 studies reported the frequency of self reported… (moderate certainty).

1 finding from 1 review

Intervention not reported

Although a higher percentage of people in the ATL and aCCT groups fell within Class I (seizure free) and Class II (> 50% reduction in seizures), no significant differences in seizure frequency were noted between the groups at 2 years after surgery... · people with temporal lobe epilepsy and intellectual disabilities
1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual aid (Passive) ICC = 0 (perfect vs. poor‐moderate compliance) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Video 'fairytale' vs. no audiovisual… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ 2 parents vs. 1 parent Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ 2 parents vs. 1 parent Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Parental presence vs. midazolam Poor compliance: ICC > 6 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Parental presence vs. midazolam Poor… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Low sensory stimulation vs. control (Passive) ICC = 0 · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Low sensory stimulation vs. control… (very low certainty).

1 finding from 1 review

Intervention not reported

Co‐operation during induction ‐ Mask introduction/exposure (Mask) ICC (number of children compliant) · children

It is very uncertain whether the intervention changes co‐operation during induction ‐ Mask introduction/exposure (Mask)… (very low certainty).

1 finding from 1 review