Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,191 questions · 2,354 findings · 362 reviews

No studies found 323 · 13.7%GRADE not reported 382 · 16.2%Very low 555 · 23.6%Low 597 · 25.4%Moderate 345 · 14.7%High 152 · 6.5%

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Rectal cancer · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Rectal cancer: OR 0.50 (95% CI 0.29 to 0.88), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

Effectiveness · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
  • A trial at high risk of bias (Zissis 1983) compared two different dose regimens of levamisole (treatment 2 days per week for 16 weeks; a third group received placebo). There was inconsistency in the presentation of the…
    1 study
    GRADE not reported

Higher‐dose vs lower dose

Intermediate syndrome · patients with acute organophosphate pesticide poisoning

It is very uncertain whether higher dose changes intermediate syndrome compared with lower dose (very low certainty).

1 finding from 1 review

Intervention not reported

mg/day LDL cholesterol · participants with normal or abnormal lipid profiles

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

1 finding from 1 review

Intervention not reported

mg/day LDL cholesterol · participants with normal or abnormal lipid profiles

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

1 finding from 1 review

Intervention not reported

mg/day LDL cholesterol · participants with normal or abnormal lipid profiles

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

1 finding from 1 review

Intervention not reported

mg/day LDL cholesterol · participants with normal or abnormal lipid profiles

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

1 finding from 1 review

Intervention not reported

Pravastatin 10 to 80 mg/day (6 to 156 weeks) · participants with normal or abnormal lipid profiles

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

WDAEs · participants with normal or abnormal lipid profiles

It is very uncertain whether the intervention changes WDAEs (very low certainty).

1 finding from 1 review