Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,231 questions · 3,354 findings · 394 reviews

No studies found 803 · 23.9%GRADE not reported 267 · 8%Very low 757 · 22.6%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Open surgical excision vs eccentric exercises

Participant global assessment of success (People who perceived their pain as none) · adult participants with patellar tendinopathy

Open surgical excision showed no clear difference in participant global assessment of success (People who perceived their… compared with eccentric exercises (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Overall mortality ‐ only total mesorectal excision ( · People with localised rectal carcinoma

Preoperative radiotherapy showed no clear difference in overall mortality ‐ only total mesorectal excision ( compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Hepatotoxicity · people with paracetamol (acetaminophen) overdose

It is very uncertain whether standard intravenous acetylcysteine regimen (20.5 hour) changes hepatotoxicity compared with shorter intravenous acetylcysteine regimen (12 hour) (very low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics from 0‐2 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics from 0‐2 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

Vomiting, retching, or antiemetics 0‐12 hours · people with paracetamol (acetaminophen) overdose

Standard intravenous acetylcysteine regimen (20.5 hour) may leads to lower vomiting, retching, or antiemetics 0‐12 hours compared with shorter intravenous acetylcysteine regimen (12 hour) (low certainty).

1 finding from 1 review