Findings

What do systematic reviews say?

2,447 questions · 2,590 findings · 266 reviews

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No studies found 699 · 27%GRADE not reported 289 · 11.2%Very low 614 · 23.7%Low 605 · 23.4%Moderate 322 · 12.4%High 61 · 2.4%

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…

1 finding from 1 review

Conventional occlusion versus pharmacologic penalization for amblyopia 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 612 participants
High

Any early psychological intervention vs active control

Depressive symptoms · various

1 finding from 1 review

Multiple session early psychological interventions for the prevention of post‐traumatic stress disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 409 participants
Low

Any early psychological intervention vs active control

Anxiety · various

1 finding from 1 review

Multiple session early psychological interventions for the prevention of post‐traumatic stress disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 414 participants
Low

Any early psychological intervention vs active control

General functioning ‐ not measured · various

1 finding from 1 review

Multiple session early psychological interventions for the prevention of post‐traumatic stress disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 239 participants
Low

Any early psychological intervention vs active control

Dropout · various

Any early psychological intervention may leads to higher dropouts from treatment compared with active control condition (low certainty).

1 finding from 1 review

Multiple session early psychological interventions for the prevention of post‐traumatic stress disorder 2019 · Cochrane Headline outcomes only
RR 1.61 [1.11, 2.34]
2 studies · 425 participants
Low

Any early psychological intervention vs active control

Severity of PTSD symptoms · various

1 finding from 1 review

Multiple session early psychological interventions for the prevention of post‐traumatic stress disorder 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 465 participants
Low

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

Weight or BMI (at end of 12 months from the start of treatment) · participants with anorexia nervosa

Summary of findings: Specialist inpatient care for weight restoration showed no clear difference in weight or BMI (at end of 12 months from the start of treatment) compared with active outpatient or combination brief hospital/outpatient care (low certainty).

1 finding from 1 review

Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 232 participants
Low

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

Secondary outcome: acceptability of treatment · participants with anorexia nervosa

It is very uncertain whether summary of findings: Specialist inpatient care for weight restoration changes acceptability: number of participants who completed treatment (at… compared with active outpatient or combination brief hospital/outpatient care (very low certainty).

1 finding from 1 review

Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders 2019 · Cochrane Headline outcomes only
RR 0.75 [0.64, 0.88]
3 studies · 319 participants
Very low

Positional therapy vs inactive control

Adherence · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
Low

Positional therapy vs inactive control

Adverse effects Measured as number of participants who discontinued device at end of 2 months · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 101 participants
Low

Positional therapy vs inactive control

Quality of life Assessed using SF‐36 or FOSQ · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 86 participants
Moderate

Positional therapy vs inactive control

Sleep quality Assessed by average duration of slow‐wave and REM sleep periods · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Low

Positional therapy vs inactive control

Cognitive dysfunction · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 86 participants
Very low

Positional therapy vs inactive control

Daytime sleepiness (ESS): change from baseline. · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 187 participants
Moderate

Positional therapy vs inactive control

AHI · adults with obstructive sleep apnoea

1 finding from 1 review

Positional therapy for obstructive sleep apnoea 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 277 participants
Low

Opioids vs active comparators

Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs active comparators

Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs active comparators

PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

Opioids vs active comparators

Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs active comparators

Any adverse event ( · adults with sickle cell disease in a vaso‐occlusive crisis

1 finding from 1 review

Pharmacological interventions for painful sickle cell vaso‐occlusive crises in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 124 participants
Very low