Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,692 questions · 2,586 findings · 180 reviews · Dental caries

No studies found 194 · 7.5%GRADE not reported 1,937 · 74.9%Very low 248 · 9.6%Low 136 · 5.3%Moderate 52 · 2%High 19 · 0.7%

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Plaque · Children aged 4 to 12 years attending primary school

Primary school-based behavioural intervention (both oral hygiene and… showed no clear difference in plaque indices (permanent and deciduous teeth) compared with no intervention or delayed intervention (non-intervention control;… (low certainty).

1 finding from 1 review
  • SoF (Plaque indices, follow-up 3 to 15 months): 'All 3 RCTs showed a reduction in plaque in the intervention group compared to control group'; 827 participants (3 RCTs); GRADE low; comment 'Data not suitable for…
    3 studies · 827 participants
    Low

Fluoride varnish vs placebo or no treatment

Proportion of children developing new caries (deciduous) · Children and adolescents aged 16 years or less

Fluoride varnish showed no clear difference in proportion of children developing one or more new caries… compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Caries occurrence on sealed teeth · Sealed permanent teeth

Glass-ionomer and resin-based fissure sealants showed no statistically significant difference in caries occurrence on sealed permanent teeth at 12 months (no GRADE rating).

3 findings from 1 review

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Secondary caries · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Costs (direct costs of interventions) · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Change in oral health knowledge and skills · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
1 finding from 1 review

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Patient's view and satisfaction with the treatment · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Resin-based fissure sealant vs Glass-ionomer cement-based fissure sealants

Retention-to-caries risk ratio (RCR) · Patients with fissure-sealed permanent molar teeth

In the sensitivity analysis, the difference in retention-to-caries risk ratio between resin- and glass-ionomer cement-based sealants was not statistically significant (p = 0.069; ungraded).

2 findings from 1 review

Resin composite restorations containing antibacterial agents vs Non-antibacterial containing composite restorations

Adverse effects · Adults and adolescents in any age group with restorations in the permanent dentition and children with restorations in the primary dentition

The review found no eligible studies for this question.

1 finding from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Changes in dental attendance · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Glass ionomer-based sealant vs No comparator

Association between loss of complete retention risk and caries occurrence risk · Patients with fissure-sealed permanent molar teeth

Loss of complete retention was not directly associated with caries occurrence for glass-ionomer cement-based sealants in the main analysis (regression slope 0.81, 95% CI -0.07 to 1.68; ungraded).

2 findings from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Behavioural outcomes (reported and/or other measures, e.g. data tracking toothbrushes and collecting food wrappers) · Children aged 4 to 12 years attending primary school

The review found no eligible studies for this question.

1 finding from 1 review