What do systematic reviews say?

1,655 questions · 1,751 findings · 147 reviews · Pain, Palliative and Supportive Care

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No studies found 361 · 20.6%GRADE not reported 87 · 5%Very low 625 · 35.7%Low 367 · 21%Moderate 232 · 13.2%High 79 · 4.5%

Intervention not reported

Pain‐free at 30 mins · adults with cluster headache

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 15 mins · adults with cluster headache

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

At least one AE · adults with cluster headache

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Serious AE · adults with cluster headache

The review found no eligible studies for this question.

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain‐free at 15 mins · adults with cluster headache

It is very uncertain whether the intervention changes pain‐free at 15 mins (very low certainty).

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
RR 2.6 [0.8, 8.5]
Studies not reported
Very low

Intervention not reported

Headache relief at 30 mins · adults with cluster headache

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 15 mins · adults with cluster headache

It is very uncertain whether the intervention changes headache relief at 15 mins (very low certainty).

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
RR 2.2 [0.99, 4.67]
Studies not reported
Very low

Intervention not reported

At least one AE · adults with cluster headache

It is very uncertain whether the intervention changes at least one AE (very low certainty).

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
RR 1.8 [1.2, 2.8]
Studies not reported
Very low

Intervention not reported

Serious AE · adults with cluster headache

The review found no eligible studies for this question.

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain‐free at 30 mins · adults with cluster headache

The review found no eligible studies for this question.

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain‐free at 15 mins · adults with cluster headache

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 30 mins · adults with cluster headache

The review found no eligible studies for this question.

1 finding from 1 review

Triptans for acute cluster headache 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain‐free at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1447 participants
Moderate

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1447 participants
Moderate

Intervention not reported

Sustained pain‐free at 24 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1578 participants
Moderate

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

At least one AE · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1075 participants
Low

Intervention not reported

Serious AE · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Naproxen 500 mg or 825 mg vs placebo

Pain‐free at 2 hours · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Naproxen 500 mg or 825 mg vs placebo

Headache relief at 2 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate