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Evidence found and GRADE certainty

4,410 questions · 8,901 findings · 1,091 reviews

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No studies found 1,687 · 19%GRADE not reported 1,469 · 16.5%Very low 1,969 · 22.1%Low 2,060 · 23.1%Moderate 1,302 · 14.6%High 414 · 4.7%

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Late paracetamol vs placebo or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Late paracetamol showed no clear difference in necrotizing enterocolitis during initial hospital stay (by… compared with placebo/no intervention (low certainty).

1 finding from 1 review

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

1 finding from 1 review

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Paracetamol plus ibuprofen (oral or IV) showed no clear difference in necrotizing enterocolitis during initial hospital stay (radiological… compared with ibuprofen plus placebo (oral or IV) or no intervention (low certainty).

1 finding from 1 review

Paracetamol vs ibuprofen

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm or low birth weight infants with PDA

Paracetamol showed no clear difference in necrotizing enterocolitisduring initial hospital stay (by… compared with ibuprofen (moderate certainty).

1 finding from 1 review

Yoga vs sham yoga

Back‐specific functional status · patients with non‐specific chronic low back pain

The review found no eligible studies for this question.

1 finding from 1 review

Yoga vs no exercise

Clinical improvement Assessed as participant rating that back pain was improved or resolved. Improvement measured differently in each study · patients with non‐specific chronic low back pain

Yoga may leads to higher clinical improvement Assessed as participant rating that back pain… compared with non‐exercise (low certainty).

1 finding from 1 review

Yoga vs no exercise

Adverse events (1 participant withdrew due to increased back pain) · patients with non‐specific chronic low back pain

Yoga may leads to higher adverse events (1 participant withdrew due to increased back pain) compared with non‐exercise (low certainty).

1 finding from 1 review

Yoga vs exercise

Clinical improvement Assessed as participant rating that back pain was improved or resolved. Improvement measured differently in each study · patients with non‐specific chronic low back pain

It is very uncertain whether yoga changes clinical improvement Assessed as participant rating that back pain… compared with exercise (very low certainty).

1 finding from 1 review