Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,703 questions · 3,824 findings · 858 reviews

No studies found 573 · 15%GRADE not reported 383 · 10%Very low 993 · 26%Low 1,062 · 27.8%Moderate 614 · 16.1%High 199 · 5.2%

NSAIDs vs combination (paracetamol and opioid) analgesic

Little or no pain at 1 to 3 days · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes little or no pain at 1 to 3 days compared with combination (paracetamol and opioid) analgesic (very low certainty).

2 findings from 1 review

NSAIDs vs combination (paracetamol and opioid) analgesic

Return to function on day 7 or later Assessed as 'cure' · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or later Assessed as 'cure' compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review