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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,325 questions in 216 reviews · Airways
current versionsNo studies 249 · 10.7%Ungraded 107 · 4.6%Very low 276 · 11.9%Low 751 · 32.3%Moderate 718 · 30.9%High 224 · 9.6%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR Dropouts due to adverse event ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 5018(4 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.6 [0.38, 0.95] | 4 studies · 5018 participants | High |
Intervention NR Dropouts due to adverse event ‐ HD TRIPLE vs MD TRIPLE№ of participants: 1765(2 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 1 [0.29, 3.44] | 2 studies · 1765 participants | Moderate |
Intervention NR Dropouts due to adverse event ‐ TRIPLE vs DUAL№ of participants: 8223(5 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.59 [0.33, 1.03] | 5 studies · 8223 participants | Moderate |
Intervention NR Total studies: 11 RCTs Total Participants: 13209 · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 11 studies · 13209 participants | Ungraded |
Intervention NR HD‐ICS/LABA (Direct evidence; 6 RCTs; 6244 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 6 studies · 6244 participants | High |
Intervention NR MD‐TRIPLE (Direct evidence; 3 RCTs; 3188 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3188 participants | Moderate |
Intervention NR Moderate to severe exacerbations ‐ MD TRIPLE vs MD‐ICS/LABA№ of participants: 3184(3 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.86 [0.75, 0.99] | 3 studies · 3184 participants | Moderate |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 2039 participants) · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 2039 participants | High |
Intervention NR MD‐ICS/LABA · Adolescent sand adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Total studies: 12 RCTs Total Participants: 12915 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 12 studies · 12915 participants | Ungraded |
Intervention NR HD‐ICS/LABA (Direct evidence; 7 RCTs; 5949 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 7 studies · 5949 participants | High |
Intervention NR MD‐TRIPLE (Direct evidence; 3 RCTs; 3188 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3188 participants | Moderate |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 2039 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 2039 participants | High |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Total studies: 12 RCTs Total Participants: 12915 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 12 studies · 12915 participants | Ungraded |
Intervention NR HD‐ICS/LABA (Direct evidence; 7 RCTs; 5969 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 7 studies · 5969 participants | High |
Intervention NR MD‐TRIPLE (Direct evidence; 3 RCTs; 3205 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3205 participants | Moderate |
Intervention NR Moderate to severe exacerbations ‐ HD TRIPLE vs MD‐ICS/LABA№ of participants: 2037(2 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.78 [0.66, 0.92] | 2 studies · 2037 participants | High |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 2051 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 2051 participants | Moderate |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Moderate to severe exacerbations ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 2651(2 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 1.05 [0.78, 1.41] | 2 studies · 2651 participants | Low |
Intervention NR Moderate to severe exacerbations ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 4989(4 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.83 [0.75, 0.92] | 4 studies · 4989 participants | High |
Intervention NR Moderate to severe exacerbations ‐ HD TRIPLE vs MD TRIPLE№ of participants: 3470(3 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.85 [0.72, 1.01] | 3 studies · 3470 participants | Moderate |
Intervention NR HD‐ICS/LABA (Direct evidence; 7 RCTs; 7023 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 7 studies · 7023 participants | Moderate |
Intervention NR Moderate to severe exacerbations ‐ TRIPLE vs DUAL№ of participants: 8173(5 RCTs) Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | RR 0.85 [0.78, 0.92] | 5 studies · 8173 participants | High |
Intervention NR Total studies: 10 RCTs Total Participants: 12407 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 10 studies · 12407 participants | Ungraded |
Intervention NR HD‐ICS/LABA (Direct evidence; 6 RCTs; 5452 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 6 studies · 5452 participants | High |
Intervention NR MD‐TRIPLE (Direct evidence; 3 RCTs; 3184 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3184 participants | Moderate |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 2037 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 2037 participants | High |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR HD Triple vs. MD Triple · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR HD‐TRIPLE (Direct evidence; 3 RCTs; 3470 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3470 participants | Moderate |
Intervention NR MD Triple · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Total studies: 4 RCTs Total Participants: 4529 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 4 studies · 4529 participants | Ungraded |
Intervention NR MD‐TRIPLE (Direct evidence; 2 RCTs; 1023 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1023 participants | Low |
Intervention NR HD‐ICS/LABA (Direct evidence; 3 RCTs; 2450 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 2450 participants | Moderate |
Intervention NR MD‐TRIPLE (Direct evidence; 1 RCT; 768 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 1 study · 768 participants | Low |
Intervention NR HD‐TRIPLE (Direct evidence; 1 RCT; 764 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 1 study · 764 participants | Low |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | 1 | NR | Ungraded |
Intervention NR Total studies: 6 RCTs Total Participants: 7957 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 6 studies · 7957 participants | Ungraded |
Intervention NR HD‐ICS/LABA (Direct evidence; 3 RCTs; 3762 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3762 participants | Moderate |
Intervention NR MD‐TRIPLE (Direct evidence; 2 RCTs; 1961 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1961 participants | Moderate |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 1952 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1952 participants | Moderate |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | 1 | NR | Ungraded |
Intervention NR Total studies: 5 RCTs Total Participants: 5440 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 5 studies · 5440 participants | Ungraded |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 1024 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1024 participants | Low |
Intervention NR HD‐ICS/LABA (Direct evidence; 3 RCTs; 3152 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 3 studies · 3152 participants | Moderate |
Intervention NR MD‐TRIPLE (Direct evidence; 2 RCTs; 1366 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1366 participants | Moderate |
Intervention NR HD‐TRIPLE (Direct evidence; 2 RCTs; 1379 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | no estimate extracted | 2 studies · 1379 participants | Moderate |
Intervention NR MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator… Effectiveness and tolerability of dual and triple combination inhaler therapies compared with each other and… (2022) · Cochrane | 1 | NR | Ungraded |