Findings

What do systematic reviews say?

185 questions · 222 findings · 37 reviews · Pain, Palliative and Supportive Care

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No studies found 32 · 14.4%GRADE not reported 12 · 5.4%Very low 74 · 33.3%Low 56 · 25.2%Moderate 42 · 18.9%High 6 · 2.7%

Paracetamol 1000 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Paracetamol 1000 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paracetamol 500 mg to 650 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for acute treatment of episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ketoprofen 25 mg vs placebo

Pain‐free at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Ketoprofen 25 mg vs placebo

Pain‐free at different time points (1, 4, 24 hours) · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Ketoprofen 25 mg vs placebo

Pain‐free or mild pain at 2 hours · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Ketoprofen 25 mg vs placebo

Use of rescue medication · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Ketoprofen 25 mg vs placebo

Any adverse event · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Ketoprofen 25 mg vs placebo

Specific adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Ketoprofen 25 mg vs placebo

Serious adverse events · adults with episodic tension‐type headache

1 finding from 1 review

Ketoprofen for episodic tension‐type headache in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Pain free at 2 hours · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1052 participants
Moderate

Intervention not reported

Pain free at 1 hour · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 711 participants
Moderate

Intervention not reported

Global evaluation 'very good' or 'excellent' · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 739 participants
Moderate

Intervention not reported

Use of rescue medication over 6 hours · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 589 participants
Low

Intervention not reported

Adverse events · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 1645 participants
High

Intervention not reported

Serious adverse events · Adults with episodic tension‐type headache

1 finding from 1 review

Ibuprofen for acute treatment of episodic tension‐type headache in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

SSRIs or SNRIs vs placebo

Headache (frequency) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 127 participants
Low

SSRIs or SNRIs vs other antidepressants

Headache duration (hours) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

SSRIs or SNRIs vs other antidepressants

Symptomatic/analgesic medication use for acute headache attacks · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low