Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

206 questions · 209 findings · 20 reviews · Pregnancy and Childbirth

No studies found 44 · 21.1%GRADE not reported 13 · 6.2%Very low 49 · 23.4%Low 55 · 26.3%Moderate 40 · 19.1%High 8 · 3.8%

Vaginal PGE2 vs intravenous (IV) oxytocin

Caesarean section · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in caesarean section compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

80 mL vs Foley catheter

Vaginal delivery not achieved within 24 hours · pregnant women who previously had a lower segment CS and now have a singleton cephalic presentation after at least 36 completed weeks, not…

80 mL showed no clear difference in vaginal delivery not achieved within 24 hours compared with 30 mL Foley catheter (moderate certainty).

1 finding from 1 review

Vaginal PGE2 pessary vs vaginal PGE2

Caesarean section · women with a previous caesarean section, a live singleton fetus (37‐42 weeks of gestation) in cephalic presentation and a reactive…

It is very uncertain whether vaginal PGE2 pessary changes caesarean section compared with vaginal PGE2 tablet (very low certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Serious neonatal morbidity or perinatal death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in serious neonatal morbidity/perinatal death compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Vaginal PGE2 vs intravenous (IV) oxytocin

Serious maternal morbidity or death · women with one previous lower segment caesarean section and requiring labour induction due to prolonged pregnancy or pre‐eclampsia,…

Vaginal PGE2 showed no clear difference in serious maternal morbidity or death compared with intravenous (IV) oxytocin (low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Hypertensive disorders of pregnancy · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes hypertensive disorders of pregnancy ‐ (any type) compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Caearean section · women diagnosed with gestational diabetes; 24‐30 weeks' gestation; singleton pregnancy.

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes caearean section compared with placebo ‐ maternal outcomes (very low certainty).

1 finding from 1 review