Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

276 questions · 290 findings · 42 reviews · Headline outcomes only

No studies found 26 · 9%GRADE not reported 17 · 5.9%Very low 82 · 28.3%Low 92 · 31.7%Moderate 66 · 22.8%High 7 · 2.4%

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Hyperkalaemia · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in hyperkalaemia compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Death · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in death compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review

Non‐steroidal mineralocorticoid receptor antagonist vs selective aldosterone antagonist

Doubling serum creatinine · proteinuric chronic kidney disease

Non‐steroidal mineralocorticoid receptor antagonist showed no clear difference in doubling serum creatinine compared with selective aldosterone antagonist (low certainty).

1 finding from 1 review