What do systematic reviews say?

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

The review found no eligible studies for this question.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  No studies reported data for this outcome.
  Studies not reported
  No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes

  3 months (change from baseline)
  MD 0.44 [-0.20, 1.08]
  6 studies · 244 participants
  GRADE not reported
• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes

  6 months (change from baseline)
  MD -0.04 [-0.19, 0.10]
  3 studies · 125 participants
  Very low

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

The review found no eligible studies for this question.

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  No studies reported data for this outcome.
  Studies not reported
  No studies found

Adjunctive antimicrobial photodynamic therapy (aPDT) applied after subgingival instrumentation (SI) vs Subgingival instrumentation (SI) alone (hand or power-driven, or both), or SI plus placebo/sham aPDT

• Adjunctive antimicrobial photodynamic therapy for treating periodontal and peri‐implant diseases 2024 · Cochrane All outcomes
  Risk with control: In 1 study, 1 participant had an abscess (not specified if this was related to aPDT). In 2 other studies, no adverse effects of aPDT were observed. Number of participants (studies): 134 (3 RCTs).…
  3 studies · 134 participants
  Moderate

Amifostine vs no treatment/placebo

• Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy 2017 · Cochrane All outcomes

  End of RT
  Mean per-patient supportive care costs lower with amifostine (USD 4401) than control (USD 5873); P = 0.02 (Buntzel 1998 / Bennett 2001)
  1 study · 28 participants
  GRADE not reported

SPT using one technique or appliance for mechanical root debridement vs SPT using a different technique or appliance for mechanical root debridement

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes bleeding on probing (%) compared with SPT performed by specialists (specialist practice) (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 7.40 [-8.12, 22.92]
  1 study · 35 participants
  Very low

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

It is very uncertain whether SPT performed by non-specialist clinicians (general dental… changes probing pocket depth (mm) compared with SPT performed by specialists (specialist practice) (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 0.20 [-0.40, 0.80]
  1 study · 35 participants
  Very low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  OR 0.45 [0.14, 1.52]
  1 study · 50 participants
  Very low

SPT provided at one time interval vs SPT provided at a different time interval

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  See comment. Killeen 2016 reported no adverse events at follow-up examinations in either study arm. Tonetti 2012 reported that there were no serious adverse events.
  2 studies · 251 participants
  GRADE not reported

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD -0.10 [-0.59, 0.39]
  1 study · 51 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes

  12 months
  MD 0.10 [-0.42, 0.62]
  1 study · 53 participants
  Low

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

SPT performed by non-specialist clinicians (general dental practitioners under specialist prescription) vs SPT performed by specialists (specialist practice)

The review found no eligible studies for this question.

• Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis 2018 · Cochrane All outcomes
  Not measured
  0 studies
  No studies found

ACT subsidies combined with supportive interventions vs no subsidies

• Subsidising artemisinin‐based combination therapy in the private retail sector 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26626 participants
  High

ACT subsidies combined with supportive interventions vs no subsidies

• Subsidising artemisinin‐based combination therapy in the private retail sector 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 2 participants
  High

ACT subsidies combined with supportive interventions vs no subsidies

• Subsidising artemisinin‐based combination therapy in the private retail sector 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  Very low