Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Intervention not reported

Variceal band ligation(9 RCTs, 879 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes variceal band ligation(9 RCTs, 879 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Beta‐blockers + variceal band ligation(1 RCT, 173 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

The intervention may leads to lower beta‐blockers + variceal band ligation(1 RCT, 173 participants) (low certainty).

1 finding from 1 review

Intervention not reported

Variceal band ligation(17 RCTs, 1640 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes variceal band ligation(17 RCTs, 1640 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Beta‐blockers + variceal band ligation(2 RCTs, 313 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding

It is very uncertain whether the intervention changes beta‐blockers + variceal band ligation(2 RCTs, 313 participants) (very low certainty).

1 finding from 1 review

Intervention not reported

Beta‐blockers plus Nitrates plus Variceal band ligation(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding

The intervention showed no clear difference in beta‐blockers plus Nitrates plus Variceal band ligation(No direct RCT) (low certainty).

1 finding from 1 review

Intervention not reported

Beta‐blockers plus Variceal band ligation(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding

The intervention showed no clear difference in beta‐blockers plus Variceal band ligation(No direct RCT) (low certainty).

1 finding from 1 review

Sclerotherapy vs no intervention

Serious adverse events and liver‐related morbidity: incidence of gastric varices · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes serious adverse events and liver‐related morbidity: incidence of… compared with no intervention (very low certainty).

1 finding from 1 review

Sclerotherapy vs no intervention

Serious adverse events and liver‐related morbidity: incidence of bleeding from gastric varices · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes serious adverse events and liver‐related morbidity: incidence of… compared with no intervention (very low certainty).

1 finding from 1 review

Sclerotherapy vs no intervention

Oesophageal variceal bleeding · primary prophylaxis of oesophageal variceal bleeding in children with chronic liver disease or portal vein thrombosis

It is very uncertain whether sclerotherapy changes oesophageal variceal bleeding compared with no intervention (very low certainty).

1 finding from 1 review

Supine midline head position vs any other supine head position

Intraventricular haemorrhage · very preterm infants with or at risk of germinal matrix‐intraventricular haemorrhage in preterm infants

It is very uncertain whether supine midline head position changes intraventricular haemorrhage, any grade compared with any other supine head position (very low certainty).

1 finding from 1 review