TCAs with predominantly SRI actions vs placebo
Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 16 participantsVery low
Findings
What do systematic reviews say?
3,584 questions · 3,695 findings · 567 reviews
No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%
TCAs with predominantly SRI actions vs other TCAs
Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania
1 finding from 1 review
- no estimate extracted1 study · 26 participantsLow
Band ligation vs no intervention or a sham procedure
Oesophageal variceal bleeding · children with portal hypertension and large oesophageal varices, without previous gastrointestinal bleeding or beta‐blocker treatment
It is very uncertain whether band ligation changes oesophageal variceal bleeding compared with sham or no intervention (very low certainty).
1 finding from 1 review
- Band ligation versus sham or no intervention for primary prophylaxis of oesophageal variceal bleeding in children and… 2021 · Cochrane Headline outcomes onlyRR 0.28 [0.03, 2.27]1 study · 22 participantsVery low
Intervention not reported
Variceal band ligation(5 RCTs, 372 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(5 RCTs, 372 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyOR 0.75 [0.02, 23.24]Studies not reportedVery low
Intervention not reported
Variceal band ligation(1 RCT, 168 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedLow
Intervention not reported
Variceal band ligation(7 RCTs, 728 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(7 RCTs, 728 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyOR 1.6 [0.54, 5.15]Studies not reportedVery low
Intervention not reported
Variceal band ligation(4 RCTs, 480 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedLow
Intervention not reported
Beta‐blockers + variceal band ligation(1 RCT, 140 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
Intervention not reported
Variceal band ligation(5 RCTs, 380 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(5 RCTs, 380 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 1.41 [0.83, 2.43]Studies not reportedVery low
Intervention not reported
Variceal band ligation(3 RCTs, 330 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(3 RCTs, 330 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 0.8 [0.47, 1.36]Studies not reportedVery low
Intervention not reported
Variceal band ligation(9 RCTs, 879 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(9 RCTs, 879 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 0.72 [0.33, 1.51]Studies not reportedVery low
Intervention not reported
Beta‐blockers + variceal band ligation(1 RCT, 173 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
The intervention may leads to lower beta‐blockers + variceal band ligation(1 RCT, 173 participants) (low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 0.21 [0.04, 0.71]Studies not reportedLow
Intervention not reported
Variceal band ligation(2 RCTs, 130 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
Intervention not reported
Variceal band ligation(17 RCTs, 1640 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes variceal band ligation(17 RCTs, 1640 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 1.05 [0.8, 1.38]Studies not reportedVery low
Intervention not reported
Beta‐blockers + variceal band ligation(2 RCTs, 313 participants) · people with liver cirrhosis and oesophageal varices with no history of bleeding
It is very uncertain whether the intervention changes beta‐blockers + variceal band ligation(2 RCTs, 313 participants) (very low certainty).
1 finding from 1 review
- Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network… 2021 · Cochrane Headline outcomes onlyHR 1.11 [0.56, 2.19]Studies not reportedVery low
Intervention not reported
Sclerotherapy plus Variceal band ligation(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in sclerotherapy plus Variceal band ligation(No direct RCT) (low certainty).
1 finding from 1 review
- Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated… 2021 · Cochrane Headline outcomes onlyHR 0.78 [0.35, 1.76]Studies not reportedLow
Intervention not reported
Beta‐blockers plus Nitrates plus Variceal band ligation(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in beta‐blockers plus Nitrates plus Variceal band ligation(No direct RCT) (low certainty).
1 finding from 1 review
- Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated… 2021 · Cochrane Headline outcomes onlyHR 0.89 [0.4, 1.98]Studies not reportedLow
Intervention not reported
Beta‐blockers plus Variceal band ligation(No direct RCT) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in beta‐blockers plus Variceal band ligation(No direct RCT) (low certainty).
1 finding from 1 review
- Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated… 2021 · Cochrane Headline outcomes onlyHR 0.83 [0.22, 3.05]Studies not reportedLow
Intervention not reported
Variceal band ligation(1 RCT; 100 participants) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention may leads to lower variceal band ligation(1 RCT; 100 participants) (low certainty).
1 finding from 1 review
- Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated… 2021 · Cochrane Headline outcomes onlyOR 0.19 [0.06, 0.53]Studies not reportedLow
Intervention not reported
Variceal band ligation(3 RCTs; 215 participants) · people with liver cirrhosis and previous oesophageal variceal bleeding
The intervention showed no clear difference in variceal band ligation(3 RCTs; 215 participants) (low certainty).
1 finding from 1 review
- Secondary prevention of variceal bleeding in adults with previous oesophageal variceal bleeding due to decompensated… 2021 · Cochrane Headline outcomes onlyOR 0.39 [0.16, 1.09]Studies not reportedLow