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Evidence found and GRADE certainty

275 questions · 298 findings · 28 reviews · Dementia and Cognitive Improvement

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No studies found 47 · 15.8%GRADE not reported 9 · 3%Very low 45 · 15.1%Low 60 · 20.1%Moderate 104 · 34.9%High 33 · 11.1%

Donepezil 10 mg/day vs placebo

Secondary outcome: acceptability of treatment · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Risk for at least one adverse event per patient · people with severe Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 24 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Clinician‐rated global impression test (improved compared with baseline assessed using CIBIC‐plus at 24 weeks) · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher clinician‐rated global impression tests (improved compared with… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Acceptability · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher acceptability of treatment (as measured by withdrawals from trial… compared with placebo (moderate certainty).

1 finding from 1 review

Donepezil 10 mg/day vs placebo

Risk for at least one adverse event per patient · people with Alzheimer's disease

Donepezil 10 mg/day probably leads to higher incidence of adverse events (at least one adverse event by 26 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo

Number of responders · patients with depression and dementia

Antidepressant treatment showed no clear difference in number of responders (ITT) at 6 to 12 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Risk for at least one adverse event per patient · patients with depression and dementia

Antidepressant treatment probably leads to higher number of patients experiencing at least one adverse event compared with placebo (moderate certainty).

1 finding from 1 review

Valproate vs placebo

Behavioural problems: agitation or aggression · people with agitation in dementia
3 findings from 1 review

Valproate vs placebo

Any adverse event by 6 weeks · people with agitation in dementia

Valproate preparations may leads to higher any adverse event by 6 weeks compared with placebo (low certainty).

1 finding from 1 review