Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

537 questions · 560 findings · 45 reviews · Common Mental Disorders

No studies found 105 · 18.8%GRADE not reported 8 · 1.4%Very low 170 · 30.4%Low 153 · 27.3%Moderate 94 · 16.8%High 30 · 5.4%

Antidepressant plus antipsychotic vs placebo plus antidepressant

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes clinical response of depression compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Leaving the study early · adults with psychotic depression

It is very uncertain whether antidepressant plus antipsychotic changes overall dropouts compared with placebo plus antidepressant (very low certainty).

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Change in depression severity from baseline · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Antidepressant plus antipsychotic vs placebo plus antidepressant

Acceptability ‐ dropouts due to adverse effects · adults with psychotic depression

The review found no eligible studies for this question.

2 findings from 1 review

Antipsychotics vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Adverse events Study reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes adverse eventsStudy reports compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ remission) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ remission)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ response) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ response)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Quality of lifeValidated quality of life scales as used by authors, CGI (7‐point scale) where possible, higher scores indicate poorer quality of life · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Trial non‐completionStudy reports · adults with Major Depressive Disorder

It is very uncertain whether n3PUFAs changes trial non‐completionStudy reports compared with placebo (very low certainty).

1 finding from 1 review

Antioxidants vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review