Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain
2 findings from 1 review
Adverse events (reported in the first 7 days after the procedure) · children with acute postoperative pain
1 finding from 1 review
Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relief of pain · children with acute postoperative pain
The review found no eligible studies for this question.
2 findings from 1 review
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Pain · postoperative pain in preterm and term infants
1 finding from 1 review
Major neurodevelopmental disability in children aged 18 to 24 months CA · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Major neurodevelopmental disability in children aged 3 to 5 years CA · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cognitive and educational outcomes in children more than five years old · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality during hospital stay · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · postoperative pain in preterm and term infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Outcome№ of participants(studies) · children with acute postoperative pain
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Relief of pain · children with acute postoperative pain
2 findings from 1 review
no estimate extracted
50 participants
GRADE not reported
no estimate extracted
50 participants
GRADE not reported
Pain intensity ‐ as reported by child, at 0 to 2 hours № of participants: 180 (2 RCTs) · children with acute postoperative pain
1 finding from 1 review
Pain intensity ‐ as reported by child, at 2 to 24 hours № of participants: 300 (3 RCTs) · children with acute postoperative pain
1 finding from 1 review
Nausea and vomiting · children with acute postoperative pain
It is very uncertain whether diclofenac changes nausea, vomiting, or both during study period № of participants: 348… compared with paracetamol (very low certainty).
1 finding from 1 review
Any bleeding during study period № of participants: 100(2 RCTs)d · children with acute postoperative pain
It is very uncertain whether diclofenac changes any bleeding during study period № of participants: 332 (5 RCTs) compared with paracetamol (very low certainty).
1 finding from 1 review
Serious adverse events during the study period · children with acute postoperative pain
It is very uncertain whether diclofenac changes serious adverse events during study period № of participants: 60 (1… compared with paracetamol (very low certainty).
1 finding from 1 review
Ibuprofen vs placebo
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Menstrual blood loss: mean loss
Interventions (ibuprofen, tolfenamic acid, aspirin, tranexamic acid) showed no clear difference in menstrual blood loss (alkaline hematin method) compared with placebo or active comparators (paracetamol, tranexamic acid); GRADE not reported.
2 findings from 1 review
MD 14.11
Studies not reported
GRADE not reported
MD 0.3
Studies not reported
GRADE not reported