Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

668 questions · 685 findings · 68 reviews · Headline outcomes only

No studies found 181 · 26.4%GRADE not reported 16 · 2.3%Very low 151 · 22%Low 211 · 30.8%Moderate 98 · 14.3%High 28 · 4.1%

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Myocardial infarction · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in myocardial infarction compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Cardiac mortality · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation showed no clear difference in cardiac death compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Transcatheter aortic valve implantation vs surgical aortic valve replacement

Permanent pacemaker implantation · adults with severe aortic stenosis who are at a low surgical risk.

Transcatheter aortic valve implantation probably leads to higher permanent pacemaker implantation compared with surgical aortic valve replacement (moderate certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Pain at rest on arrival in postoperative care unit Visual/verbal analogue scale · adults undergoing elective primary total hip replacement

Peripheral nerve blocks showed no clear difference in pain at rest on arrival in postoperative care unit Visual/verbal… compared with systemic analgesia (moderate certainty).

1 finding from 1 review

Peripheral nerve block vs neuraxial block

Aute confusional state Disorientation · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve block changes aute confusional state Disorientation compared with neuraxial block (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Acute confusional state Complete loss of time and space orientation · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes acute confusional state Complete loss of time and space orientation compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Length of hospital stay · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes hospital length of stay Objective actual measurement compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Walking at postoperative day 1 Objective actual measurement · adults undergoing elective primary total hip replacement

It is very uncertain whether peripheral nerve blocks changes walking at postoperative day 1 Objective actual measurement compared with systemic analgesia (very low certainty).

1 finding from 1 review

Peripheral nerve block vs systemic analgesia

Patient satisfaction Subjective scales · adults undergoing elective primary total hip replacement

Peripheral nerve blocks may leads to higher patient satisfaction Subjective scales compared with systemic analgesia (low certainty).

1 finding from 1 review

Peripheral nerve block vs neuraxial block

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults undergoing elective primary total hip replacement

Peripheral nerve block showed no clear difference in pain at rest on arrival in postoperative care unit Verbal/visual… compared with neuraxial block (moderate certainty).

1 finding from 1 review

Heparin vs placebo

Symptomatic VTE · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Heparin showed no clear difference in symptomatic VTE (DVT and PE) Treatment duration 28 ‐ 42 days compared with placebo (high certainty).

1 finding from 1 review

Vitamin K antagonists vs placebo

Major bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Vitamin K antagonists showed no clear difference in bleeding ‐ major Treatment duration 28 ‐ 42 days compared with placebo (low certainty).

1 finding from 1 review