Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

214 questions · 217 findings · 40 reviews · Pain, Palliative and Supportive Care

No studies found 35 · 16.1%GRADE not reported 2 · 0.9%Very low 49 · 22.6%Low 43 · 19.8%Moderate 48 · 22.1%High 40 · 18.4%

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 h (high certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 1 adverse event · adults with moderate or severe acute postoperative pain

The intervention showed no clear difference in participants with at least 1 adverse event (moderate certainty).

1 finding from 1 review

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 hours (high certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 1 adverse event · adults with moderate or severe acute postoperative pain

The intervention showed no clear difference in participants with at least 1 adverse event (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain‐free response at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

Sustained pain‐free during the 24 h post dose · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

Sustained headache relief during the 24 h post dose · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

At least one AE · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review

Intervention not reported

Serious AE* · adults with migraine headache ‐ moderate or severe pain
1 finding from 1 review