Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Titrated oxygen therapy vs high‐flow oxygen therapy

Mortality (respiratory‐ related and all‐cause · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy may leads to lower mortality (respiratory‐ related and all‐cause compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Titrated oxygen therapy vs high‐flow oxygen therapy

Ventilation of any type · adults with acute exacerbations of chronic obstructive pulmonary disease

Titrated oxygen therapy showed no clear difference in ventilation of any type compared with high‐flow oxygen therapy (low certainty).

1 finding from 1 review

Anti‐angiogenic therapy vs no anti‐angiogenic therapy

Overall survival ( · people with HGG

Anti‐angiogenic therapy showed no clear difference in overall survival ( compared with no anti‐angiogenic therapy (high certainty).

4 findings from 1 review
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Anti‐angiogenic therapy vs no anti‐angiogenic therapy

Progression‐free survival · people with HGG

Anti‐angiogenic therapy leads to lower progression‐free survival ( compared with no anti‐angiogenic therapy (high certainty).

4 findings from 1 review
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Intravenous iron vs oral iron

Ferritin (µg/L) · people with preoperative anaemia awaiting major surgery

Intravenous iron therapy may leads to higher ferritin preoperatively postintervention (ng/L) compared with oral iron therapy (low certainty).

1 finding from 1 review

Intravenous iron vs oral iron

Haemoglobin (g/dL) · people with preoperative anaemia awaiting major surgery

Intravenous iron therapy may leads to higher haemoglobin levels at end of preoperative treatment (g/dL) compared with oral iron therapy (low certainty).

2 findings from 1 review

Present‐centered therapy vs trauma‐focused cognitive behavioral therapy

Dropout from treatment (a count of participants not meeting study‐defined completion threshold) · adults aged ≥ 16 years with PTSD

Present‐centered therapy probably leads to lower treatment dropout compared with trauma‐focused cognitive behavioral therapy (moderate certainty).

1 finding from 1 review