Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

237 questions · 238 findings · 41 reviews · Musculoskeletal

No studies found 43 · 18.1%GRADE not reported 7 · 2.9%Very low 48 · 20.2%Low 89 · 37.4%Moderate 39 · 16.4%High 12 · 5%

Any cold therapy vs no cold therapy following total knee replacement

Adverse events Adverse events included discomfort, local skin reactions, superficial infections, cold induced injuries and thrombolytic events · people undergoing total knee replacement

It is very uncertain whether any cold therapy changes total adverse eventsAdverse events included discomfort, local skin… compared with no cold therapy following total knee replacement (very low certainty).

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Proportion participants that switched to another biologic due to loss of response ‐ not measured · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

The review found no eligible studies for this question.

1 finding from 1 review

Anti‐TNF discontinuation vs anti‐TNF continuation

Proportion of participants with minimal radiographic progression · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents

Anti‐TNF discontinuation leads to higher proportion participants with minimal radiographic progression compared with anti‐TNF continuation (high certainty).

1 finding from 1 review