Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

350 questions · 366 findings · 36 reviews · Heart

No studies found 50 · 13.7%GRADE not reported 15 · 4.1%Very low 79 · 21.6%Low 121 · 33.1%Moderate 72 · 19.7%High 29 · 7.9%

Lipopeptide antibiotic (daptomycin) vs aminoglycoside (low‐dose gentamicin) plus anti‐staphylococcal penicillin (nafcillin, oxacillin or flucloxacillin) or glycopeptide antibiotic (vancomycin)

Need for cardiac surgical interventions · people with endocarditis caused by Staphylococcus aureus

The review found no eligible studies for this question.

1 finding from 1 review

Glycopeptide (vancomycin or teicoplanin) plus aminoglycoside (gentamicin) vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Need for cardiac surgical interventions · people with endocarditis due to Staphylococcus aureus in drug abusers

The review found no eligible studies for this question.

1 finding from 1 review

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

Fosfomycin plus imipenem vs vancomycin

Need for cardiac surgical interventions · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes need for cardiac surgical interventions compared with vancomycin (very low certainty).

1 finding from 1 review

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

Need for cardiac surgical interventions · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes need for cardiac surgicalinterventions compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

Advance care planning vs usual care

Quality of communication Measured on Quality of Patient‐Clinician Communication About End‐of‐Life Care. Higher score indicates high satisfaction with the quality of communication Assessed after intervention · people with heart failure with or without their surrogate decision‐makers/carers
1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Long‐term all‐cause mortality (≥ 1 year after the intervention) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term all‐cause mortality (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Cardiovascular mortality · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term cardiovascular mortality (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Myocardial infarction · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term myocardial infarction (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Short‐term all‐cause mortality (within the first 30 days after the intervention) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes short‐term all‐cause mortality (within the first 30 days after the… compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Complete revascularisation vs culprit‐only revascularisation

Long‐term revascularisation (≥ 1 year after the intervention) · people with STEMI and MVD.

It is very uncertain whether complete revascularisation changes long‐term revascularisation (≥ 1 year after the intervention) compared with culprit‐only revascularisation (very low certainty).

1 finding from 1 review

Intervention not reported

Recurrent pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower recurrent pericarditis Chest pain + (ECG changes +/‐… (moderate certainty).

1 finding from 1 review

Intervention not reported

Acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic changes +/‐ raised inflammatory markers) Intervention: colchicine with NSAID; Comparison: NSAID alone

The intervention probably leads to lower acute pericarditis Chest pain + (ECG changes +/‐ echocardiographic… (moderate certainty).

1 finding from 1 review

Intervention not reported

Enrolment · adults (age 18 years or over) with myocardial infarction, stable angina, following coronary artery bypass graft surgery or percutaneous…

The intervention may leads to higher enrolment (low certainty).

1 finding from 1 review

Intervention not reported

Adherence · adults (age 18 years or over) with myocardial infarction, stable angina, following coronary artery bypass graft surgery or percutaneous…
1 finding from 1 review

Intervention not reported

Completion · adults (age 18 years or over) with myocardial infarction, stable angina, following coronary artery bypass graft surgery or percutaneous…

The intervention probably leads to higher completion (moderate certainty).

1 finding from 1 review