Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

489 questions · 504 findings · 104 reviews

No studies found 32 · 6.3%GRADE not reported 63 · 12.5%Very low 152 · 30.2%Low 133 · 26.4%Moderate 103 · 20.4%High 21 · 4.2%

Needle aspiration (needle removed immediately after aspiration) vs intercostal tube drainage

Need for intercostal tube drainage · patients with pneumothorax in the newborn

It is very uncertain whether needle aspiration (needle removed immediately after aspiration) changes need for intercostal tube drainage compared with intercostal tube drainage (very low certainty).

1 finding from 1 review

Infliximab combined with purine analogues vs purine analogues

Clinical relapse · Participants with Crohn's disease in remission

Infliximab combined with purine analogues probably leads to lower clinical relapse (at 48 weeks, CDAI of 150 or greater together with… compared with purine analogues (moderate certainty).

1 finding from 1 review

Effects of extensive instructions vs simple instructions

PAR pass rate (%) ‐ Fit testing of foam earplugs (immediate) · workers exposed to noise using HPDs

Effects of extensive instructions probably leads to higher PAR pass rate (%) ‐ Fit testing of foam earplugs (immediate) compared with simple instructions (moderate certainty).

1 finding from 1 review

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

Discomfort/pain · Adolescents and adults with malocclusion undergoing orthodontic treatment with fixed or removable appliances

Light vibrational forces (LVF) showed no clear difference in patient perception of pain and discomfort (VAS 0 to 100 mm),… compared with conventional orthodontic appliance treatment (placebo or no adjunct) (low certainty).

1 finding from 1 review