Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Minocycline 45 mg vs minocycline 45 mg + azelaic acid gel

Proportion of participants with adverse event · Participants with rosacea

Minocycline 45 mg showed no clear difference in proportion of participants with adverse event compared with minocycline 45 mg + azelaic acid gel (low certainty).

1 finding from 1 review

NB‐UVB plus retinoid vs PUVA plus retinoid

Percentage of participants reaching PASI 75 · People with chronic plaque or guttate psoriasis

NB‐UVB plus retinoid showed no clear difference in percentage of participants reaching PASI 75 compared with PUVA plus retinoid (low certainty).

1 finding from 1 review

Allopurinol vs placebo

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Acute gout attacks · people with chronic gout

Allopurinol showed no clear difference in acute gout attacks compared with benzbromarone (low certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Proportion achieving target serum urate · people with chronic gout

Allopurinol showed no clear difference in proportion achieving target serum urate compared with benzbromarone (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Pain reduction ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Function ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs benzbromarone

Tophus regression ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Allopurinol vs placebo

Proportion achieving target serum urate · people with chronic gout

Allopurinol probably leads to higher proportion achieving target serum urate compared with placebo (moderate certainty).

1 finding from 1 review

Allopurinol vs benzbromarone

Withdrawals due to adverse events · people with chronic gout

Allopurinol showed no clear difference in withdrawal due to adverse events compared with benzbromarone (low certainty).

1 finding from 1 review