Primary outcome: prevention of ulcer · ulceration and other skin changes caused by nerve damage in leprosy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ulcer healing · ulceration and other skin changes caused by nerve damage in leprosy
2 findings from 1 review
Primary outcome 3: Adverse events · ulceration and other skin changes caused by nerve damage in leprosy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Secondary outcome: quality of life · ulceration and other skin changes caused by nerve damage in leprosy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Secondary outcome: acceptability of treatment · ulceration and other skin changes caused by nerve damage in leprosy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cost of the intervention · ulceration and other skin changes caused by nerve damage in leprosy
1 finding from 1 review
Dental caries · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
Pooling 3 studies, children/adolescents with CLP were about 2.03 times more likely to have dental caries than non-CLP controls (p<0.005; low heterogeneity), though most included studies were at high risk of bias; the evidence is ungraded.
1 finding from 1 review
Lactobacillus spp. salivary/plaque counts (cariogenic microbiota) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
A meta-analysis found no significant difference in mean Lactobacillus spp. levels between children with and without CLP, with high heterogeneity; the evidence is ungraded.
1 finding from 1 review
Streptococcus mutans count · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
A meta-analysis of 2 studies found no difference in mean Streptococcus mutans levels between children with and without CLP, with very high heterogeneity; the evidence is ungraded.
1 finding from 1 review
Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded.
1 finding from 1 review
Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).
1 finding from 1 review
Cariogenic and commensal oral bacteria (S. mutans and commensal streptococci growth, adhesion, biofilm) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
Most in vitro studies indicate e-cigarette aerosol/e-liquid (especially flavored/high-concentration) disrupts normal oral flora and favors cariogenic S. mutans growth and biofilm, plausibly increasing caries risk; not pooled (ungraded, narrative).
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
A trim-and-fill sensitivity analysis pooling every exposure estimate gave an overall OR of 0.17 (95% CI 0.13-0.21) after correcting for significant publication bias (Fig. 13); this combined estimate spans heterogeneous exposures and is a publication-bias sensitivity result (ungraded).
1 finding from 1 review
Pulp exposure rate · Patients with deep carious lesions in permanent (mainly posterior) teeth
Minimally invasive caries removal was associated with a lower mean pulp exposure rate than conventional removal (1.2% vs 8.1%), but the difference was not statistically significant (Wilcoxon, p = 0.068); certainty of evidence was not graded.
1 finding from 1 review
Mean pulp-exposure percentage (unweighted study-level mean, 4 studies) MIT 1.2% vs CT 8.1% (Wilcoxon = 0.0, p = 0.068; not statistically significant)
4 studies · 791 participants
GRADE not reported
Congruence between informed values and choice ‐ all studies Based on the proportion of participants who made a decision that aligned with what was most important to them. Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions
Patient decision aids probably leads to higher congruence between informed values and choice ‐ all studies Based on… compared with usual care (moderate certainty).
1 finding from 1 review
Knowledge · adults considering treatment or screening decisions
1 finding from 1 review
Decisional conflict: decision aid versus usual care ‐ all studies ‐ Uninformed sub‐scale standardized on score from 0 (not uninformed) to 100 (uninformed) [soon after exposure to the decision aid] · adults considering treatment or screening decisions
1 finding from 1 review
Unclear values · adults considering treatment or screening decisions
1 finding from 1 review
Mesh exposure · vaginal prolapse
Transvaginal permanent mesh probably leads to higher mesh exposure compared with native tissue repair (moderate certainty).
1 finding from 1 review
Number of women with mesh exposure, extrusion or erosion in any area · women with urinary incontinence
Single‐incision slings showed no clear difference in number of women with mesh exposure, extrusion or erosion in any area compared with retropubic minimally‐invasive slings (low certainty).
1 finding from 1 review