Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

183 questions · 195 findings · 14 reviews

No studies found 51 · 26.2%GRADE not reported 17 · 8.7%Very low 53 · 27.2%Low 51 · 26.2%Moderate 19 · 9.7%High 4 · 2.1%

3% mepivacaine plain vs 2% lidocaine, 1:100,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

3% mepivacaine plain may leads to lower speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Adverse effects: paraesthesia following injection · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

The review found no eligible studies for this question.

1 finding from 1 review
  • SoF: See comment; 0 participants (0 studies); 1 case of prolonged anaesthesia recorded; no clinical studies met the outcome definition (unable to confirm whether prolonged anaesthesia = paraesthesia).
    0 studies
    No studies found

4% prilocaine plain vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% prilocaine plain may leads to lower success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% articaine plain vs 4% articaine, 1:100,000 epinephrine

Duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine plain changes duration of anaesthesia (pulpal, electric pulp tester; healthy pulps) compared with 4% articaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review

4% articaine plain vs 4% articaine, 1:200,000 epinephrine

Speed of onset of anaesthesia (pulpal, electric pulp tester; healthy pulps) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine plain changes speed of onset of anaesthesia (pulpal, electric pulp tester; healthy… compared with 4% articaine, 1:200,000 epinephrine (very low certainty).

1 finding from 1 review

3% prilocaine, 0.03 IU felypressin vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia, absence of pain (clinical testing of healthy pulps, hard and soft tissues) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

3% prilocaine, 0.03 IU felypressin probably leads to lower success of local anaesthesia, absence of pain (clinical testing of… compared with 2% lidocaine, 1:100,000 epinephrine (moderate certainty).

1 finding from 1 review

2% mepivacaine, 1:20,000 levonordefrin vs 2% lidocaine, 1:100,000 epinephrine

Success of local anaesthesia (clinical; orphan data) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…
1 finding from 1 review
  • No data available for meta-analysis; orphan clinical success data summarized in Table 6 (e.g. clinical anaesthesia success 2% lidocaine 1:100,000 64/110 vs 2% mepivacaine 1:20,000 levonordefrin 99/113). Not…
    Studies not reported
    GRADE not reported

Dopamine vs norepinephrine

Total mortalitya · hypotensive shock

Dopamine showed no clear difference in total mortalitya compared with norepinephrine (high certainty).

1 finding from 1 review

Terlipressin vs norepinephrine

Total mortalitya · hypotensive shock

It is very uncertain whether terlipressin changes total mortalitya compared with norepinephrine (very low certainty).

1 finding from 1 review

Vasopressin vs norepinephrine

Total mortalitya · hypotensive shock

Vasopressin showed no clear difference in total mortalitya compared with norepinephrine (moderate certainty).

1 finding from 1 review

Phenylephrine vs norepinephrine

Total mortalitya · hypotensive shock

It is very uncertain whether phenylephrine changes total mortalitya compared with norepinephrine (very low certainty).

1 finding from 1 review