Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

203 questions · 208 findings · 26 reviews · Neonatal

No studies found 3 · 1.4%GRADE not reported 23 · 11.1%Very low 59 · 28.4%Low 107 · 51.4%Moderate 12 · 5.8%High 4 · 1.9%

Fish oil lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

All fish oil containing LE showed no clear difference in retinopathy of prematurity (≥ stage 3) compared with S‐LE (low certainty).

1 finding from 1 review

Alternative lipid emulsion (LE) vs S‐LE

Severe (defined as stage 3 or greater) retinopathy of prematurity ‐ not reported · Parenterally fed preterm infants

It is very uncertain whether all alternative LE changes retinopathy of prematurity (≥ stage 3) compared with S‐LE (very low certainty).

1 finding from 1 review

Intervention not reported

Bayley MDI at 12 months post‐term · Preterm infants on enteral feed

The intervention showed no clear difference in bayley MDI at 12 months post‐term (low certainty).

1 finding from 1 review

Intervention not reported

Bayley PDI at 12 months post‐term · Preterm infants on enteral feed

The intervention showed no clear difference in bayley PDI at 12 months post‐term (low certainty).

1 finding from 1 review

Intervention not reported

Weight at 12 months post‐term (kg) · Preterm infants on enteral feed

The intervention showed no clear difference in weight at 12 months post‐term (kg) (low certainty).

1 finding from 1 review

Intervention not reported

Length at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in length at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Intervention not reported

Head circumference at 12 months post‐term (cm) · Preterm infants on enteral feed

The intervention showed no clear difference in head circumference at 12 months post‐term (cm) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Growth during the first month of life · preterm born neonates
3 findings from 1 review

Summary of findings table ‐ Early amino acids vs Late amino acids

Neurodevelopmental outcomes · preterm born neonates

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

1 finding from 1 review