Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

572 questions · 579 findings · 55 reviews · Headline outcomes only

No studies found 60 · 10.4%GRADE not reported 42 · 7.3%Very low 205 · 35.4%Low 210 · 36.3%Moderate 52 · 9%High 10 · 1.7%

Lactoferrin supplementation with enteral feeds in combination with probiotics vs placebo

NEC ≥ stage II · prevention of sepsis and necrotizing enterocolitis in preterm infants

It is very uncertain whether lactoferrin supplementation with enteral feeds in combination with… changes NEC ≥ stage II compared with placebo (very low certainty).

1 finding from 1 review

Standard parenteral nutrition vs standard isotonic intravenous glucose solution

Length of hospital stay after liver transplantation [days] · adult patients after liver transplantation.
2 findings from 1 review

Standard parenteral nutrition vs standard isotonic intravenous glucose solution

Mortality [within first 10 weeks after liver transplantation] · adult patients after liver transplantation.

Standard parenteral nutrition may leads to lower mortality [within first 10 weeks after liver transplantation] compared with standard isotonic intravenous glucose solution (low certainty).

1 finding from 1 review

Inactivated influenza vaccine vs placebo or no intervention

Nausea or vomiting assessed by subjective report Timing of assessment: single influenza season · healthy adults

Inactivated parenteral influenza vaccine showed no clear difference in nausea or vomiting assessed by subjective report Timing of… compared with placebo or 'do nothing' (low certainty).

1 finding from 1 review

Immune‐enhancing supplements (oral or enteral) vs usual care or control

Infectious complications · people undergoing gastrointestinal surgery

Immune‐enhancing supplements (oral or enteral) showed no clear difference in infectious complications recorded up to 30 days postdischarge compared with usual care or control (low certainty).

1 finding from 1 review