Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

320 questions · 331 findings · 64 reviews · Headline outcomes only

No studies found 44 · 13.3%GRADE not reported 24 · 7.3%Very low 120 · 36.3%Low 90 · 27.2%Moderate 37 · 11.2%High 16 · 4.8%

Cemented vs uncemented hemiarthroplasty

Functional status, early (within 4 months): using HHS (range from 0 to 100) and Johansen hip score (range from 0 to 100); higher scores indicate better function · adults with displaced and undisplaced hip fractures
1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Mobility, early (within 4 months): able to walk outdoors using no more than 1 walking aid. · adults with displaced and undisplaced hip fractures

Cemented showed no clear difference in mobility, early (within 4 months): able to walk outdoors using no… compared with uncemented hemiarthroplasty (moderate certainty).

1 finding from 1 review

Cemented vs uncemented hemiarthroplasty

Mortality, early (within 4 months) · adults with displaced and undisplaced hip fractures

Cemented showed no clear difference in mortality, early (within 4 months) compared with uncemented hemiarthroplasty (low certainty).

1 finding from 1 review

Automated monitoring systems vs usual care

Time to initiation of antimicrobial therapy (Time to initiation starts at the time of admission) · people admitted to intensive care units

It is very uncertain whether automated monitoring systems changes time to initiation of antimicrobial therapy (Time to initiation… compared with standard care (very low certainty).

1 finding from 1 review

One‐incision vs two‐incision techniques

IKDC knee examination grade normal (grade A) or nearly normal (grade B) ‐ Intermediate/long‐term · adults undergoing arthroscopically assisted ACL reconstruction1

It is very uncertain whether one‐incision changes objective functional knee assessments using IKDC10 (intermediate… compared with two‐incision techniques (very low certainty).

1 finding from 1 review

Laser ablation vs radiofrequency ablation

Serious adverse events (number of participants) · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether laser ablation changes serious adverse events (number of participants) compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Percutaneous ethanol injection vs radiofrequency ablation

Serious adverse events (number of participants) · people with early‐ or very early‐stage hepatocellular carcinoma ineligible for surgery

It is very uncertain whether percutaneous alcohol injection changes serious adverse events (number of participants) compared with radiofrequency ablation (very low certainty).

1 finding from 1 review

Intervention not reported

Congestive heart failure (CHF) · HER2‐positive early breast cancer patients

The intervention leads to higher congestive heart failure (CHF) (high certainty).

1 finding from 1 review

Early paracetamol vs placebo or no intervention

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm or low birth weight infants with PDA

Early paracetamol may leads to lower failure of PDA closure after first course of treatment (by… compared with placebo/no intervention (low certainty).

1 finding from 1 review