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What do systematic reviews say?

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Evidence found and GRADE certainty

1,036 questions · 1,100 findings · 261 reviews

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No studies found 160 · 14.5%GRADE not reported 188 · 17.1%Very low 270 · 24.5%Low 303 · 27.5%Moderate 139 · 12.6%High 40 · 3.6%

Naldemedine vs placebo

Laxation response: patient assessment of change in bowel status at the end of trial · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Lower‐dose methylnaltrexone vs higher dose

Laxation response: patient assessment of change in bowel status at the end of trial · people receiving palliative care irrespective of whether they had cancer with opioid‐induced bowel dysfunction

Methylnaltrexone lower dose showed no clear difference in laxation response: patient assessment of change in bowel statusgat… compared with higher dose (low certainty).

1 finding from 1 review

Low dose naldemedine vs higher dose

Laxation response: patient assessment of change in bowel status at the end of trial · people with cancer irrespective of whether receiving palliative care and with opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Joint crisis plan plus treatment as usual vs treatment

Deatha Timing of outcome assessment: 12 months · community‐dwelling adults with a diagnosis of borderline personality disorder

Joint crisis plan plus treatment as usual showed no clear difference in deatha Timing of outcome assessment: 6 months compared with treatment (low certainty).

1 finding from 1 review

Brief admission to psychiatric hospital by self‐referral plus treatment as usual vs treatment

Violence perpetration · adults meeting 3 or more diagnostic criteria for borderline personality disorder

Brief admission to psychiatric hospital by self‐referral plus… showed no clear difference in violence perpetration: number of participants who perpetrated… compared with treatment (low certainty).

1 finding from 1 review

Brief admission to psychiatric hospital by self‐referral plus treatment as usual vs treatment

Deatha Timing of outcome assessment: 12 months · adults meeting 3 or more diagnostic criteria for borderline personality disorder

Brief admission to psychiatric hospital by self‐referral plus… showed no clear difference in deatha Timing of outcome assessment: 12 months compared with treatment (low certainty).

1 finding from 1 review

Prophylactic administration of paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm infants with PDA

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Summary of findings table ‐ Remifentanil vs diazepam

Surgical assessment/satisfaction score = 1 or 2 (Technically successful procedure as defined by trial authors) · health problem or population

Summary of findings table ‐ Remifentanil may leads to higher surgical assessment/satisfaction score = 1 or 2 (Technically… compared with diazepam (low certainty).

1 finding from 1 review