Findings

What do systematic reviews say?

143 questions · 144 findings · 18 reviews · Headline outcomes only

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No studies found 8 · 5.6%GRADE not reported 1 · 0.7%Very low 32 · 22.2%Low 65 · 45.1%Moderate 32 · 22.2%High 6 · 4.2%

Interleukin‐2 RA vs no induction

Mortality Mortality at latest · heart transplant recipients

Interleukin‐2 RA showed no clear difference in mortality Mortality at latest compared with no induction (low certainty).

1 finding from 1 review

Immunosuppressive T‐cell antibody induction for heart transplant recipients 2013 · Cochrane Headline outcomes only
RR 1.53 [0.85, 2.76]
4 studies · 576 participants
Low

Interleukin‐2 RA vs no induction

Acute rejection Acute rejection grade 3A or more verified by biopsy · heart transplant recipients

Interleukin‐2 RA showed no clear difference in acute rejection Acute rejection grade 3A or more verified by biopsy compared with no induction (low certainty).

1 finding from 1 review

Immunosuppressive T‐cell antibody induction for heart transplant recipients 2013 · Cochrane Headline outcomes only
RR 0.73 [0.46, 1.17]
4 studies · 576 participants
Low

Interleukin‐2 RA vs no induction

Infection Number of participants diagnosed with infection · heart transplant recipients

Interleukin‐2 RA showed no clear difference in infection Number of participants diagnosed with infection compared with no induction (low certainty).

1 finding from 1 review

Immunosuppressive T‐cell antibody induction for heart transplant recipients 2013 · Cochrane Headline outcomes only
RR 0.99 [0.79, 1.24]
3 studies · 545 participants
Low