Findings

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Oral alkylating agents ± steroids vs steroids or placebo or both, or no treatment

Adverse events ‐ infection at 3 years · primary membranous nephropathy in adults with nephrotic syndrome

It is very uncertain whether oral alkylating agents ± steroids changes adverse events ‐ infection at 3 years compared with placebo/no treatment/steroids (very low certainty).

1 finding from 1 review

CBT plus hypnosis (combined package) vs usual care

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · People aged 12 years and over with painful TMD lasting 3 months or longer

CBT plus hypnosis (combined package) led to lower pain intensity compared with usual care; GRADE not reported.

1 finding from 1 review

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

Gingivitis · Children aged 7 to 13 years with Down syndrome (mild to moderate ID); setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Toothpaste with a plaque-disclosing agent vs conventional toothpaste, children with Down syndrome. Ainamo & Bay Gingival Bleeding Index, mean 10 days; percent mean difference 18 (intervention) vs 8 (control), P<0.001…
    1 study · 40 participants
    Very low

Toothpaste with a plaque-disclosing agent vs Conventional toothpaste

Plaque · Children aged 7 to 13 years with Down syndrome (mild to moderate ID); setting residential
1 finding from 1 review
  • Oral hygiene interventions for people with intellectual disabilities 2019 · Cochrane All outcomes
    Short term (<6 weeks)
    Simplified Green & Vermillion Oral Hygiene Index (plaque), mean 10 days; percent mean difference 65 (intervention) vs 15 (control), P<0.0001 favouring the disclosing-agent toothpaste; 40 participants (SoF states 80,…
    1 study · 40 participants
    Very low

Psychosocial risk management ('Resettle' programme) vs usual care

Death during study period · adults with antisocial personality disorder

It is very uncertain whether psychosocial risk management ('Resettle' programme) changes adverse events: death during the study period Timing of assessment:… compared with treatment‐as‐usual (very low certainty).

1 finding from 1 review

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal death (death within the first 28 days of life) · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality in the first 28 days of life compared with cholera toxoid (low certainty).

1 finding from 1 review

Tetanus diphtheria toxoid immunisation of women of reproductive age vs cholera toxoid

Neonatal mortality between day 4‐14 of life · women of reproductive age ≥ 15 years.

Tetanus diphtheria toxoid immunisation of women of reproductive age may leads to lower neonatal mortality between day 4‐14 of life compared with cholera toxoid (low certainty).

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Clinical assessment: alveolar ridge healing (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher clinical assessment: alveolar ridge healing (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: periapical film (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: periapical film (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Length of hospital stay · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to lower length of hospital stay (days) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Postoperative complication: persistent oronasal fistula · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… showed no clear difference in postoperative complication: persistent oronasal fistula compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: three-dimensional CT scan (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: three-dimensional CT scan (0 to 3 grading… compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Number of participants discharged on the same day as surgery · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher number of participants discharged on the same day as surgery compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Clinical assessment: nasal alar base augmentation (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… showed no clear difference in clinical assessment: nasal alar base augmentation (0 to 3 grading… compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: Panorex scan (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: Panorex scan (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Postoperative complication: (partial) loss of bone graft · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… showed no clear difference in postoperative complication: (partial) loss of bone graft compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Referral to specialist agencies for support in relation to domestic violence vs no intervention

Severity of injury by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review

Referral to specialist agencies for support in relation to domestic violence vs no intervention

Frequency of physical assault by self report · Adults (16 years of age and older) who present to any healthcare setting with dental or facial injury

The review found no eligible studies for this question.

1 finding from 1 review